Intraocular bevacizumab for macular edema due to CRVO. A multifocal-ERG and OCT study

Documenta Ophthalmologica. Advances in Ophthalmology
Marilita M Moschos, Michael Moschos

Abstract

To evaluate by multifocal electroretinography (MFERG) and optical coherence tomography (OCT) the effectiveness of intravitreal use of bevacizumab (Avastin) in the treatment of macular edema due to central retinal vein occlusion (CRVO). A total of 10 eyes of 10 patients (six males and four females) with macular edema due to CRVO were studied before and after intravitreal use of bevacizumab with MFERG and OCT. The post treatment follow-up was 3 months. Examination included measurement of best-corrected visual acuity (BCVA) for distance, measurement of intraocular pressure (IOP), fluorescein angiography, foveal-retinal thickness measurement by OCT, and MFERG recordings before treatment and 1 and 3 months after treatment. Before treatment, OCT shows an increase of the retinal thickness of the fovea. About 1 and 3 months after treatment the foveal thickness decreased to a significant level. The electrical responses in the fovea and parafovea of the MFERG recording depicted a significant improvement at 1 and 3 months after the injection. No patient manifested IOP increase. The intravitreal use of bevacizumab may provide anatomical and functional amelioration of the macula in patients with macular edema due to CRVO. However, further s...Continue Reading

References

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Citations

Dec 31, 2010·Japanese Journal of Ophthalmology·Masafumi OtaNagahisa Yoshimura
Aug 27, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Zi Ye JinJost B Jonas
Sep 1, 2011·Retina·Kevin W Bronson-CastainAnthony J Adams
Oct 1, 2008·BMC Ophthalmology·Mathias AbeggJohannes Fleischhauer
Aug 12, 2009·Clinical Ophthalmology·Juan Carlos Mesa GutiérrezJorge Arruga Ginebreda
Jun 8, 2014·Documenta Ophthalmologica. Advances in Ophthalmology·Ivana Gardašević TopčićPolona Jaki Mekjavić
Nov 3, 2009·Journal français d'ophtalmologie·S Nghiem-Buffet, S-Y Cohen
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May 12, 2009·Clinical & Experimental Ophthalmology·Atsushi SakamotoNagahisa Yoshimura
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Mar 28, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Tomoharu NishimuraYuji Hara

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