PMID: 6168980Jul 17, 1981Paper

Intraocular colchicine selectively destroys immature ganglion cells in chicken retina

Neuroscience Letters
I G Morgan

Abstract

Low doses of colchicine (greater than 0.5 microgram) injected into the eyes of young chickens irreversibly inhibit axonal transport of material labelled with [3H]fucose. This is due to almost total destruction of the retinal ganglion cells, while other retinal cell types, including the displaced amacrine cells found in the same retinal layer, survive the treatment. The neurotoxic effect of colchicine on chick retinal ganglion cells decreases after hatching, and it is suggested that the decrease in sensitivity may be related to myelination of the retinal ganglion cell axons.

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Citations

Feb 11, 1991·Neuroscience Letters·A M SheppardP L Jeffrey
Feb 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kanika GhaiAndy J Fischer
Dec 15, 2007·Experimental Eye Research·Vivian ChohChristine F Wildsoet
Dec 22, 2004·Progress in Retinal and Eye Research·Andy J Fischer
Feb 26, 2013·Experimental Eye Research·Marita Feldkaemper, Frank Schaeffel
May 26, 1999·Vision Research·A J FischerW K Stell
Mar 25, 2008·Developmental Biology·Andy J FischerAngela Wynne
Nov 17, 2009·Current Opinion in Neurology·Anne-Caroline Bessero, Peter G H Clarke
Jun 3, 2020·The Journal of Comparative Neurology·Sally A McFadden, Christine Wildsoet
May 12, 2011·Biomedical Optics Express·Alireza Akhlagh MoayedKostadinka Bizheva
Feb 16, 2013·Biomedical Optics Express·Carla J AbbottBrad Fortune
Nov 19, 2002·Developmental Biology·Andy J Fischer, Thomas A Reh

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