PMID: 653577Mar 1, 1978Paper

Intraocular hemorrhages: a hemostatic therapeutic approach

Survey of Ophthalmology
M Pandolfi

Abstract

Our knowledge of the local hemostatic factors capable of playing a role in certain intraocular hemorrhages is reviewed as a background to therapy with agents active in hemostasis. Common to hyphemas and subretinal hemorrhages are some conditions which are apt to disturb hemostasis and result in recurrent bleeding. They are: 1) Dilution of blood by aqueous humor or subretinal exudative fluid followed by the formation of hemostatic plugs which are prone to spontaneous lysis; 2) Contiguity of certain structures, such as the iris and the choroid, which are extremely rich in fibrinolytic activators favoring premature dissolution of the hemostatic plug and thereby recurrent bleeding; and 3) Presumptive high local concentration of fibrin degradation products (FDP), which have an anticoagulant action and would counteract hemostasis in the event of rebleeding. Based on these observations, the use of fibrinolytic inhibitors for the treatment of hyphema and subretinal hemorrhages seems warranted. Hemostatic mechanisms in intraocular hemorrhages and their treatment with various agents are discussed.

References

Mar 1, 1976·American Journal of Ophthalmology·E R Crouch, M Frenkel
Aug 1, 1976·Acta Ophthalmologica·T Jerndal, M Frisén
Aug 12, 1976·Biochimica Et Biophysica Acta·L HolmbergB Astedt
Apr 1, 1976·Journal of Neurosurgery·R P SenguptaF J Villarejo-Ortega
Feb 1, 1976·Experimental Eye Research·J V ForresterJ Williamson
Jul 1, 1973·Lancet·J Forrester, J Williamson
Apr 1, 1968·Physiological Reviews·J A Schilling
May 1, 1973·American Journal of Ophthalmology·W N Dugmore, M Raichand
Dec 1, 1973·The British Journal of Ophthalmology·S H Sarks
Jan 1, 1973·Scandinavian Journal of Haematology·H Arnesen, H C Godal
Mar 1, 1968·Biochemical Pharmacology·T Astrup
Jan 1, 1967·Archives of Ophthalmology·M Pandolfi, H C Kwaan
Dec 1, 1971·The British Journal of Ophthalmology·W Rakusin
Jun 28, 1968·Annals of the New York Academy of Sciences·L AnderssonB Melander
May 1, 1967·Journal of Clinical Pathology·M J Gallimore
Jun 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·P MOLTKE
Jan 1, 1962·Acta Ophthalmologica·E GREGERSEN
Feb 1, 1963·Archives of Ophthalmology·H G SCHEIED T BURNS
Jan 1, 1963·Acta Ophthalmologica·I HORVEN
Nov 1, 1963·The British Journal of Ophthalmology·S D PAUL, O P AHUJA
Jul 1, 1965·American Journal of Ophthalmology·C MILTHALERR F BINDER
Jan 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·M PANDOLFIT ASTRUP
Jul 1, 1967·Journal of Clinical Pathology·G R Fearnley

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Citations

Jul 1, 1997·Survey of Ophthalmology·C W Spraul, H E Grossniklaus
Nov 1, 1982·Australian Journal of Ophthalmology·K R Littlewood
Sep 1, 1979·Experimental Eye Research·L FehrenbacherM A Shuman
Feb 27, 2007·Optometry : Journal of the American Optometric Association·Marie I Bodack
Jun 25, 2009·European Journal of Ophthalmology·Hamid R Jahadi HosseiniShohreh A Simakani
Jun 1, 1983·Acta Ophthalmologica·P Vangsted, P J Nielsen
Jun 1, 1979·Acta Ophthalmologica·T Bramsen
Jun 1, 1982·Experimental Eye Research·J V ForresterJ Williamson

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