PMID: 8594638Jan 1, 1995Paper

Intraocular injection of ceftazidime. Effects of inflammation and surgery

Retina
A ShaarawyR M Reichley

Abstract

The clearance of ceftazidime from the rabbit vitreous cavity after injection into phakic, aphakic, and aphakic vitrectomized rabbit eyes was assessed and the duration of concentrations above the minimal inhibitory concentrations for target gram-negative bacteria was determined. To determine the effect of inflammation on the intraocular pharmacokinetics of ceftazidime, each anatomic group was subdivided into inflamed and control eyes. Ceftazidime (2.25 mg) was into the vitreous cavity of inflamed and control rabbit eyes and its concentration was assayed 2, 8, 24, and 48 hours later. The half-life for each of the anatomic groups was calculated. The half-life of ceftazidime in control phakic eyes was 13.8 hours. In aphakic eyes the half-life was 11.8 hours and in the aphakic vitrectomized eyes the half-life was 4.7 hours. Inflammation slightly shortened the half-life in phakic (10.1 hours) and aphakic (8.7 hours) eyes. The half-life in aphakic vitrectomized inflamed eyes was 5.1 hours. Vitrectomy and lensectomy significantly shorten the half-life of ceftazidime after intravitreal injection. Inflammation increases clearance to a small degree in phakic and aphakic eyes.

Citations

Oct 22, 2002·Journal of Cataract and Refractive Surgery·Klaus D Teichmann
Oct 26, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·J WagaB Ehinger
Sep 8, 2000·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·R M CocoJ C Pastor
Jul 11, 2007·Retina·Craig A Lemley, Dennis P Han
Jun 10, 2008·Journal of Clinical Microbiology·Kuan-Jen ChenMing-Hui Sun
Apr 4, 2013·Current Eye Research·John B ChristoforidisZhongfa Liu
Feb 4, 2006·Drug and Chemical Toxicology·Murat SonmezOguz Gulecek
May 28, 2011·American Journal of Ophthalmology·Kuan-Jen ChenNan-Kai Wang
Nov 15, 2017·Expert Opinion on Drug Metabolism & Toxicology·Magdalena EdingtonNgaihang Victor Chong
Feb 11, 2015·Journal of Ophthalmic Inflammation and Infection·Medikonda RadhikaHarry W Flynn
Mar 20, 2020·Pharmaceutics·Rubén Varela-FernándezFrancisco J Otero-Espinar

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