Intraocular levels of methotrexate after intravenous administration

American Journal of Ophthalmology
M D de SmetR B Nussenblatt

Abstract

To determine if adequate intraocular levels of methotrexate are achieved after intravenous administration. After intravenous administration, methotrexate levels were determined in the serum, the anterior chamber, and the cerebrospinal fluids of a patient with recurrent ocular lymphoma. A fluorescence polarization immunoassay was used to make the determinations. At seven hours into a 24-hour intravenous infusion, methotrexate was at cytotoxic level in all samples. At 74 hours, cytotoxic levels were present only in the aqueous humor. Sustained cytotoxic ocular methotrexate levels are achievable after systemic administration.

References

Jun 1, 1991·Journal of Neuro-oncology·F H HochbergM Prados
Oct 1, 1990·International Ophthalmology·M D de SmetA G Palestine

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Citations

Jan 27, 2004·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Eric Tourville, Yvon Tardif
Mar 29, 2002·Survey of Ophthalmology·Russell W ReadNarsing A Rao
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alain P AlgaziJames L Rubenstein
Dec 22, 2004·Current Oncology Reports·Stella K KimDana J Wallace
Jul 11, 2006·Ocular Immunology and Inflammation·Robert B NussenblattUNKNOWN CNS and Ocular Lymphoma Workshop Group
Sep 14, 2007·Current Eye Research·Esther Eljarrat-BinstockJacob Pe'er
Jul 3, 2003·Clinical Lymphoma·Adilia Hormigo, Lisa M DeAngelis
Jul 9, 2004·British Journal of Haematology·Adília HormigoLisa M DeAngelis
Oct 22, 2004·Seminars in Oncology·Lisa M Deangelis, Adília Hormigo
Feb 25, 2014·Survey of Ophthalmology·Mandeep S SagooSue Lightman
Jan 4, 2005·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Joachim PuchtaHolger Baatz
Jul 27, 2011·Therapeutic Advances in Medical Oncology·Nooshin Hashemi-Sadraei, David M Peereboom
Feb 8, 2014·Korean Journal of Ophthalmology : KJO·Choul Yong ParkJong-Hyun Oh
Oct 3, 2006·Japanese Journal of Ophthalmology·Jia-Kang WangHwei-Fang Tien
Feb 10, 2009·Retina·Sujit Itty, Jose S Pulido
Apr 18, 2001·Current Opinion in Oncology·R R BuggageR B Nussenblatt
May 15, 2020·Ocular Immunology and Inflammation·Arash MalekiCharles Stephen Foster
Sep 21, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Chi-Chao Chan, Dana J Wallace
May 25, 2016·Cancer Control : Journal of the Moffitt Cancer Center·Matthew T Witmer
Jun 1, 2011·Journal of Neuro-oncology·Gregory S VosganianAlan Saven
Oct 17, 2009·Ocular Immunology and Inflammation·Jacob Pe'erC Stephen Foster
Nov 5, 2019·Clinical & Experimental Ophthalmology·Michael KvopkaJustine R Smith
May 27, 2021·Blood·Carole SoussainNathalie Cassoux

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