Intraocular lymphoma in Korea: the Consortium for Improving Survival of Lymphoma (CISL) study

Blood Research
Seul LeeCheolwon Suh

Abstract

Intraocular lymphoma (IOL) is a rare malignant lymphoma that most closely resembles a diffuse large B-cell lymphoma, and it is a subtype of primary central nervous system lymphoma (PCNSL). IOL is located inside the eye in the retina, uvea, and/or optic nerve. We retrospectively analyzed IOL patient data to identify treatment patterns and survival rates in Korea. Cytological confirmation for a diagnosis of IOL was performed for all patients. The clinical data collected from medical records included Ann Arbor stage, International Prognostic Index, performance status, date of diagnosis, treatment modality and response, date of relapse, and date of last follow-up. Twenty patients who were diagnosed with IOL, between December 2007 and June 2014 at multiple centers in Korea, were included in the analysis. Four patients were diagnosed with IOL alone, not involving the CNS. Two patients with isolated IOL later developed PCNSL. Nine patients developed CNS lesions before the onset of ocular lymphoma. Five patients had simultaneous onset in the eye and CNS. Twelve patients were treated by intravitreal injection of methotrexate for IOL. The median progression-free survival (PFS) for patients was 19.7 months (95% CI, 8.7-30.7 mo). The estim...Continue Reading

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Citations

Nov 17, 2017·British Journal of Haematology·Ayako KarakawaMakoto Aihara
Mar 15, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Takako ItoKoh-Hei Sonoda
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Nov 19, 2019·Journal of Ophthalmology·Victor LlorençAlfredo Adán
Feb 15, 2020·Survey of Ophthalmology·Alexandra L Farrall, Justine R Smith

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Methods Mentioned

BETA
ICE
biopsy

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