Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC

American Journal of Ophthalmology
Frederick A JakobiecA E Korshunov

Abstract

To compare immunohistochemical and genetic overlaps and differences between intraocular medulloepitheliomas and embryonal tumors with multilayered rosettes of the brain. Retrospective histopathologic, immunohistochemical, and genetic analysis of 20 intraocular medulloepitheliomas. (1) Review of clinical data and hematoxylin-eosin-stained sections with (2) immunohistochemical staining of paraffin sections using a polyclonal antibody against the protein LIN28A, and (3) fluorescence in situ hybridization (FISH) testing for the amplification of the genetic locus 19q13.42 involving the C19MC cluster of miRNA. Ten retinoblastomas served as controls and to determine the specificity of these biomarkers for intraocular medulloepitheliomas. Nineteen of the 20 intraocular medulloepitheliomas were either diffusely or focally LIN28A positive (weak, moderate, or strong). The most intense positivity correlated with aggressive behavior such as intraocular tissue invasion or extraocular extension. None of the cases studied by FISH harbored an amplicon for C19MC. The 10 retinoblastomas were LIN28A and C19MC negative. LIN28A has a putative role in oncogenesis and is found only in embryonic cells and malignancies. Intraocular medulloepitheliomas a...Continue Reading

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Citations

Feb 5, 2016·Genes, Chromosomes & Cancer·Felix SahmAndrey Korshunov
Aug 17, 2019·Current Molecular Medicine·Sacha Nahon-EstevePaul Hofman
Feb 12, 2017·Oncotarget·Patrícia Benites Gonçalves da SilvaOswaldo Keith Okamoto
May 26, 2017·Journal of Pathology and Translational Medicine·Sung-Hye ParkSeung-Hong Choi
Jul 1, 2020·Acta Neuropathologica·Sander LamboMarcel Kool
Oct 23, 2020·Journal of Neuro-oncology·Nikhil RaghuramAnnie Huang
Nov 26, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Aruna NambirajanMehar Chand Sharma
May 20, 2020·Ophthalmic Plastic and Reconstructive Surgery·Ryan A GalloAndrew J Rong
Apr 18, 2019·Journal of Pediatric Hematology/oncology·Marion HonnoratEric Bouffet
Oct 2, 2020·Ophthalmology·Hardeep Singh MudharJerry A Shields

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