PMID: 3516335Mar 1, 1986

Intraocular pressure--physiology and implications for anaesthetic management

Canadian Anaesthetists' Society Journal
A J Cunningham, P Barry


The major factors controlling intraocular pressure during surgery are the dynamic balance between aqueous humour production in the ciliary body and its elimination via the canal of Schlemm; the auto-regulation and chemical control of choridal blood volume; the extraocular muscle tone and vitreous humour volume. Prior to surgical incision of the anterior chamber in open intraocular procedures, a low-normal intraocular pressure is mandatory to avoid the hazards of iris or lens prolapse and vitreous loss associated with sudden decompression. In general, the central nervous system depressant drugs, hypnotics, narcotics, major tranquillizers, volatile anaesthetic agents are associated with a reduction in intraocular pressure, with the exception of ketamine and possibly trichloroethylene. The mechanism of action of anaesthetic agents in reducing intraocular pressure may involve a direct effect on central diencephalic control centres, reduction of aqueous production, facilitation of aqueous drainage or relaxation of extraocular muscle tone. Succinylcholine administration is associated with a significant rise in intraocular pressure, with a peak increase between two to four minutes following administration and a return to base line val...Continue Reading


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Related Concepts

Anesthesia Procedures
General Anesthesia
Anesthetic Effect
Aqueous Flare
Central Nervous System Depressants
Eye Injuries
Physiologic Intraocular Pressure
Muscle Tonus
Narcotic Effect

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