Intraocular pressure control and visual field changes in primary angle closure disease: the CUHK PACG Longitudinal (CUPAL) study

The British Journal of Ophthalmology
Carol Y CheungClement C Tham

Abstract

To determine the relationship of intraocular pressure (IOP) control with subsequent visual field (VF) deterioration in patients with primary angle closure disease (PACD). 419 PACD eyes from 240 Chinese patients were included. Mean IOP and IOP fluctuation were calculated as the average and SD divided by mean IOP, respectively, of all the IOP measured in the initial 18 months for assessment of IOP control. The relationship between IOP control and subsequent VF parameters over time was examined using linear mixed models. VF deterioration was defined as IOP control associated with decreased VF parameters over time with a p value <0.05. We calculated the average of the mean IOPs and IOP fluctuations in the cohort and used these two average values as a cut-off point to define high-threshold (≥average value) or low-threshold (<average value) for mean IOP and IOP fluctuation for each PACD eye, respectively. Greater IOP fluctuation was significantly associated with VF deterioration, independent of mean IOP (mean deviation (MD) β=-6.36, p=0.03; VF index β=-16.41, p=0.04; and cataract-adjusted MD β=-6.96, p=0.02). In the categorical analysis, those with both high-threshold mean IOP and high-threshold IOP fluctuation had the most rapid VF ...Continue Reading

References

Jul 1, 1985·The American Journal of Physiology·B K Slinker, S A Glantz
Oct 9, 2002·Archives of Ophthalmology·Anders HeijlUNKNOWN Early Manifest Glaucoma Trial Group
Jan 14, 2003·Archives of Ophthalmology·M Cristina LeskeUNKNOWN Early Manifest Glaucoma Trial Group
Sep 8, 2004·Ophthalmology·Kouros Nouri-MahdaviUNKNOWN Advanced Glaucoma Intervention Study
Nov 14, 2006·Ophthalmology·Boel BengtssonUNKNOWN Early Manifest Glaucoma Trial Group
Nov 16, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Samin HongGong Je Seong
Mar 3, 2009·Current Opinion in Ophthalmology·Kuldev Singh, Anurag Shrivastava
May 29, 2009·Investigative Ophthalmology & Visual Science·Aachal KotechaUNKNOWN MoreFlow Study Group
Jan 7, 2010·Current Opinion in Ophthalmology·Thasarat S VajaranantCharlotte E Joslin
Apr 13, 2011·Archives of Ophthalmology·Kuldev Singh, Arthur J Sit
May 19, 2012·Journal of Glaucoma·Harsha L RaoChandra S Garudadri
Feb 5, 2013·Journal of Glaucoma·Gwyneth ReesEcosse L Lamoureux
Apr 5, 2013·Acta Ophthalmologica·Valérie BertrandThierry Zeyen
Jun 30, 2015·Acta Ophthalmologica·Carrie WrightLeslie J Katz
Aug 1, 2015·Investigative Ophthalmology & Visual Science·Shaoying TanClement C Tham
Sep 16, 2015·Journal of Glaucoma·Kaleena B MichaelJames F T Li Yim
Nov 20, 2015·Ophthalmology·Bruce E PrumRuth D Williams
Jan 24, 2018·American Journal of Ophthalmology·Xuejuan JiangUNKNOWN Los Angeles Latino Eye Study Group

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.