Intraoperative acceleration measurements to quantify improvement in tremor during deep brain stimulation surgery

Medical & Biological Engineering & Computing
Ashesh ShahSimone Hemm-Ode


Deep brain stimulation (DBS) surgery is extensively used in the treatment of movement disorders. Nevertheless, methods to evaluate the clinical response during intraoperative stimulation tests to identify the optimal position for the implantation of the chronic DBS lead remain subjective. In this paper, we describe a new, versatile method for quantitative intraoperative evaluation of improvement in tremor with an acceleration sensor that is mounted on the patient's wrist during surgery. At each anatomical test position, the improvement in tremor compared to the initial tremor is estimated on the basis of extracted outcome measures. This method was tested on 15 tremor patients undergoing DBS surgery in two centers. Data from 359 stimulation tests were acquired. Our results suggest that accelerometric evaluation detects tremor changes more sensitively than subjective visual ratings. The effective stimulation current amplitudes identified from the quantitative data (1.1 ± 0.8 mA) are lower than those identified by visual evaluation (1.7 ± 0.8 mA) for similar improvement in tremor. Additionally, if these data had been used to choose the chronic implant position of the DBS lead, 15 of the 26 choices would have been different. These ...Continue Reading


Jan 1, 1992·Biological cybernetics·C GantertJ Timmer
Apr 1, 1970·Physics in Medicine and Biology·S J Meldrum, B W Watson
Jun 6, 1997·Journal of Neuroscience Methods·C N RiviereN V Thakor
Nov 25, 1998·Brain : a Journal of Neurology·P E O'Suilleabhain, J Y Matsumoto
Nov 18, 2000·The Journal of Physiology·G P MooreH M Bronte-Stewart
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Anthony E Lang, Hakan Widner
Jun 18, 2002·IEEE Transactions on Bio-medical Engineering·Mika P TarvainenPasi A Karjalainen
Jul 9, 2004·Brain : a Journal of Neurology·Molly M SturmanDaniel M Corcos
Aug 24, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Bart PostJohannes D Speelman
Oct 18, 2005·Human Movement Science·Paul F Sowman, Kemal S Türker
Aug 8, 2006·Brain : a Journal of Neurology·Rodger J ElbleUNKNOWN Tremor Research Group
Feb 7, 2007·Medical Engineering & Physics·Henricus Louis JournéeMichiel J Staal
Dec 6, 2007·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·E RoconS J Nasuto
Dec 18, 2007·Neurophysiologie clinique = Clinical neurophysiology·H L JourneeM J Staal
Apr 5, 2008·Neuroreport·Merrill J BirdnoWarren M Grill
Jul 18, 2008·Medical & Biological Engineering & Computing·Saara M RissanenPasi A Karjalainen
Nov 26, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Movement Disorder Society UPDRS Revision Task Force
Jan 1, 2007·Critical Reviews in Biomedical Engineering·Paulo Henrique G MansurEduardo L M Naves
Jun 27, 2009·Neurologic Clinics·Mark Stacy
Oct 23, 2009·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Shyamal PatelPaolo Bonato
Jun 3, 2010·Medical & Biological Engineering & Computing·Simone Hemm, Karin Wårdell
Aug 24, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H C F MartensJerrold L Vitek
Nov 26, 2010·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Sina AskariDeborah S Won
Apr 5, 2011·Journal of Neuroscience Methods·Thomas MeraJoseph P Giuffrida
Jun 16, 2011·IEEE Transactions on Bio-medical Engineering·Saara M RissanenPasi A Karjalainen
Jul 15, 2011·Medical & Biological Engineering & Computing·Lana Popović ManeskiDejan B Popović
Oct 13, 2011·Frontiers in Integrative Neuroscience·Ali Sarem-Aslani, Keith Mullett
Dec 14, 2011·Sensors·Kalyana C Veluvolu, Wei Tech Ang
Mar 1, 2012·Physiological Measurement·A Yu MeigalM Kankaanpää
Nov 17, 2012·Stereotactic and Functional Neurosurgery·Aviva AboschMarwan I Hariz
Jan 1, 2012·Journal of Parkinson's Disease·Robert I GriffithsMalcolm K Horne
May 23, 2014·Brain : a Journal of Neurology·Claudio PolloMichael Schüpbach
Aug 26, 2014·Neurology·M Fiorella ContarinoP R Schuurman
Feb 24, 2015·Parkinsonism & Related Disorders·Christopher L PulliamJerrold L Vitek
Feb 28, 2015·Stereotactic and Functional Neurosurgery·Suhan SenovaStéphane Palfi
May 29, 2015·Medical & Biological Engineering & Computing·Thushara PereraHugh J McDermott
Jan 13, 2016·Medical & Biological Engineering & Computing·Elliot GreenwaldNitish V Thakor

❮ Previous
Next ❯


Feb 1, 2020·Medical & Biological Engineering & Computing·Ashesh ShahSimone Hemm
Feb 20, 2020·American Journal of Speech-language Pathology·Elizabeth Erickson-DiRenzoCasey H Halpern
Dec 4, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B J WilkesD E Vaillancourt

❮ Previous
Next ❯

Software Mentioned

MicroGuide Pro

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.