Intraoperative Autofluorescence Parathyroid Identification in Patients With Multiple Endocrine Neoplasia Type 1.

JAMA Otolaryngology-- Head & Neck Surgery
Malcolm H SquiresJohn E Phay

Abstract

Intrinsic near-infrared (NIR) autofluorescence of the parathyroid gland enables intraoperative gland identification without the need for contrast agent injection. However, whether real-time autofluorescence imaging is useful in patients with multiple endocrine neoplasia type 1 (MEN1) and primary hyperparathyroidism is unknown. To compare quantified intraoperative parathyroid autofluorescence imaging results for patients with MEN1-associated vs those with non-MEN1 sporadic primary hyperparathyroidism. A retrospective analysis of prospectively collected data on a cohort of 71 consecutive patients undergoing surgery for primary hyperparathyroidism by 2 experienced endocrine surgeons between June 1, 2017, and July 31, 2018, was conducted. Intraoperative imaging was performed with a handheld NIR autofluorescence device and images were captured for analysis. Post hoc blinded imaging analysis was conducted with Image J software to quantify representative areas of greatest autofluorescence from the parathyroid, thyroid, and adjacent soft tissue. Primary end points were parathyroid autofluorescence and background thyroid and soft tissue autofluorescence, reported as median values with interquartile ranges. Rates of false-negative (lack ...Continue Reading

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Citations

May 12, 2020·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Marianne MaktabiClaire Chalopin
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jonas WizentyTilo Wuensch
Mar 10, 2020·F1000Research·Melanie Goldfarb, Frederick R Singer
Oct 20, 2020·Expert Review of Endocrinology & Metabolism·Amanda WongSam M Wiseman
Dec 6, 2019·Annals of Surgery·Carmen C SolórzanoAnita Mahadevan-Jansen
Mar 9, 2021·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Chang Hwan RyuJunsun Ryu
May 7, 2021·JAMA Otolaryngology-- Head & Neck Surgery·Gregory T KennedySunil Singhal

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