Intraoperative Corneal Thickness Changes during Pulsed Accelerated Corneal Cross-Linking Using Isotonic Riboflavin with HPMC

Journal of Ophthalmology
Ahmed M SherifGeorge D Kymionis

Abstract

Purpose. To evaluate corneal thickness changes during pulsed accelerated corneal cross-linking (CXL) for keratoconus using a new isotonic riboflavin formula. Methods. In this prospective, interventional, clinical study patients with grades 1-2 keratoconus (Amsler-Krumeich classification) underwent pulsed accelerated (30 mW/cm(2)) CXL after application of an isotonic riboflavin solution (0.1%) with HPMC for 10 minutes. Central corneal thickness (CCT) measurements were taken using ultrasound pachymetry before and after epithelial removal, after riboflavin soaking, and immediately after completion of UVA treatment. Results. Twenty eyes of 11 patients (4 males, 7 females) were enrolled. Mean patient age was 26 ± 3 (range from 18 to 30 years). No intraoperative or postoperative complications were observed in any of the patients. Mean CCT was 507 ± 35 μm (range: 559-459 μm) before and 475 ± 40 μm (range: 535-420 μm) after epithelial removal (P < 0.001). After 10 minutes of riboflavin instillation, there was a statistically significant decrease of CCT by 6.2% from 475 ± 40 μm (range: 535-420 μm) to 446 ± 31 μm (range: 508-400) (P < 0.005). There was no other statistically significant change of CCT during UVA irradiation. Conclusions. ...Continue Reading

References

Apr 30, 2003·American Journal of Ophthalmology·Gregor WollensakTheo Seiler
Aug 11, 2006·Current Opinion in Ophthalmology·Gregor Wollensak
Oct 5, 2010·Ophthalmology·Nayyirih G Tahzib, Allegonda Van der Lelij
Sep 11, 2012·American Journal of Ophthalmology·Ashok SharmaVerinder Singh Nirankari
Sep 14, 2013·European Journal of Ophthalmology·Ziad HassanGabor Nemeth
Feb 27, 2014·Journal of Cataract and Refractive Surgery·Nienke SoetersNayyirih G Tahzib
Jul 12, 2014·Cornea·Vandana JainRohan Bidayi
Aug 30, 2014·Cornea·George D KymionisIoannis G Pallikaris

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