PMID: 8583329Nov 1, 1995Paper

Intraoperative detection and resection of occult neuroblastoma: a technique exploiting somatostatin receptor expression

Journal of Pediatric Surgery
D A MartinezD R King

Abstract

Tumor cell expression of specific high-affinity somatostatin receptors has been associated with a favorable prognosis in children with neuroblastoma. The purpose of this study was (1) to document intraoperatively the in vivo binding of the somatostatin analogue 125I-tyr3-octreotide to high-affinity somatostatin receptors expressed on human neuroblastoma, using a hand-held gamma detector; (2) to determine whether gamma-probe detection of radioligand binding to tumor receptors could identify occult malignancy; and (3) to determine the safety and biodistribution of 125I-tyr3-octreotide in children. Six children with stage III or IV neuroblastoma received an intravenous injection of 125I-tyr3-octreotide and underwent operative exploration using gamma-probe detection of radioligand binding to tumor somatostatin receptors. Tissue that demonstrated in vivo binding of 125I-tyr3-octreotide, or that was suspicious for tumor, was extirpated and analyzed by histopathology, immunohistochemistry, and microautoradiography. The biodistribution of 125I-tyr3-octreotide was recorded intraoperatively over time. Tumor tissue from each child also was assayed in vitro for somatostatin receptor expression by competitive binding studies using 125I-tyr3...Continue Reading

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Citations

Jan 1, 1997·Pathology Oncology Research : POR·Adorján Aszalós, Sándor Eckhardt
Mar 9, 2000·Regulatory Peptides·A R AlbersS J Qualman
Apr 9, 1999·The Journal of Peptide Research : Official Journal of the American Peptide Society·E A WolteringD H Coy
Jan 29, 2009·World Journal of Surgical Oncology·Stephen P PovoskiEdward W Martin
Aug 12, 2014·Revista española de medicina nuclear e imagen molecular·P García-TalaveraS Vidal-Sicart
Apr 30, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Ryo HottaTatsuo Kuroda
Sep 11, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Kenneth J WoodsideB Mark Evers
Jul 20, 2001·British Journal of Cancer·J C WatsonE A Woltering
Feb 16, 1999·Seminars in Surgical Oncology·G M HaaseJ B Atkinson
Dec 22, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael M Graham, Yusuf Menda

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