PMID: 6205632Sep 1, 1984Paper

Intraoperative electron beam irradiation for patients with unresectable pancreatic carcinoma

Annals of Surgery
W U ShipleyG L Nardi


Since 1978 we have used electron beam intraoperative radiation therapy (IORT) to deliver higher radiation doses to pancreatic tumors than are possible with external beam techniques while minimizing the dose to the surrounding normal tissues. Twenty-nine patients with localized, unresectable, pancreatic carcinoma were treated by electron beam IORT in combination with conventional external radiation therapy (XRT). The primary tumor was located in the head of the pancreas in 20 patients, in the head and body in six patients, and in the body and tail in three. Adjuvant chemotherapy was given in 23 of the 29 patients. The last 13 patients have received misonidazole (3.5 mg/M2) just prior to IORT (20 Gy). At present 14 patients are alive and 11 are without evidence of disease from 3 to 41 months after IORT. The median survival is 16.5 months. Eight patients have failed locally in the IORT field and two others failed regionally. Twelve patients have developed distant metastases, including five who failed locally or regionally. We have seen no local recurrences in the 12 patients who have been treated with misonidazole and have completed IORT and XRT while 10 of 15 patients treated without misonidazole have recurred locally. Because of...Continue Reading

Associated Clinical Trials


Sep 1, 1979·Annals of Surgery·A F Tryka, J R Brooks
Jul 1, 1981·International Journal of Radiation Oncology, Biology, Physics·A L GoldsonO Pearson
Dec 1, 1981·International Journal of Radiation Oncology, Biology, Physics·R WhittingtonS M Weiss
Feb 1, 1980·International Journal of Radiation Oncology, Biology, Physics·R KomakiR W Kline

❮ Previous
Next ❯


Aug 1, 1996·Cancer·H J Wanebo, M P Vezeridis
Sep 1, 1991·Journal of Surgical Oncology·A L SchurichtF E Rosato
Jan 1, 1993·Seminars in Surgical Oncology·J M JessupM Huberman
Mar 1, 1995·World Journal of Surgery·L L GundersonJ Fieck
Feb 1, 1992·Diseases of the Colon and Rectum·T J SaclaridesM S Bapna
Oct 31, 2007·Pediatric Surgery International·Kiminobu SugitoYoshiaki Tanaka
Apr 9, 2002·Current Oncology Reports·Andrew H Ko, Margaret A Tempero
Jan 1, 1996·International Journal of Radiation Oncology, Biology, Physics·Y ShibamotoM Abe
Jan 15, 1996·International Journal of Radiation Oncology, Biology, Physics·G E Hanks, R M Lanciano
Jul 19, 2001·The Surgical Clinics of North America·R Wagman, A Grann
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·M S HuqN Suntharalingam
Aug 1, 1988·International Journal of Radiation Oncology, Biology, Physics·J C FlickingerJ Webster
Nov 3, 1998·Alimentary Pharmacology & Therapeutics·A HaycoxT Walley
Feb 13, 1992·The New England Journal of Medicine·A L Warshaw, C Fernández-del Castillo
Jul 1, 1993·Annals of Surgery·D B EvansT A Rich
Feb 1, 1995·Annals of Surgery·K D Lillemoe
May 1, 1998·Journal of Clinical Gastroenterology·S Parikh, D Nori
Feb 13, 1988·British Medical Journal·R C Williamson
Jun 8, 2002·World Journal of Surgery·Rutger C I van GeenenDirk J Gouma
Jan 1, 1988·Cancer Investigation·T J Kinsella
Mar 19, 2014·Seminars in Radiation Oncology·Manisha PaltaBrian Czito
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·P HadjicostasP Symeonides
Jul 6, 2010·International Journal of Radiation Oncology, Biology, Physics·Kazuhiko OgawaUNKNOWN JROSG Working Subgroup of Gastrointestinal Cancers
Jan 1, 1990·International Journal of Radiation Oncology, Biology, Physics·A D Treurniet-DonkerW L van Putten
Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·G R GartonS S Cha
Aug 7, 2007·Seminars in Oncology·Suzanne RussoA William Blackstock
Dec 1, 1987·The Australian and New Zealand Journal of Surgery·J F Huang, J M Little
Jan 1, 1986·American Journal of Surgery·A L WarshawW U Shipley
Jan 1, 1991·American Journal of Surgery·A L Warshaw
Sep 1, 1989·International Journal of Radiation Oncology, Biology, Physics·B E PowersS J Withrow
Sep 1, 1990·International Journal of Radiation Oncology, Biology, Physics·Y ShibamotoM Abe

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.