PMID: 9179074Jun 1, 1997Paper

Intraoperative electron irradiation in the management of pediatric malignancies

Cancer
P J SchombergW A Smithson

Abstract

External beam irradiation (PBRT), especially in children, is limited by the radiosensitivity of normal tissues. Local control remains a problem in abdominopelvic childhood malignancies. Intraoperative electron irradiation (IOERT) has the potential to increase the dose to the tumor, thereby improving local control, without increasing treatment morbidity. Between February 1983 and October 1990, 11 children received IOERT as part of a multidisciplinary treatment program for locally advanced primary or recurrent abdominopelvic malignancies. The 7 boys and 4 girls ranged in age from 2-18 years. Tumor histologies included four neuroblastomas, two desmoid tumors, and one each of the following: embryonal rhabdomyosarcoma, synovial cell sarcoma, neurofibrosarcoma, malignant fibrous histiocytoma, and paraganglioma. Single radiation doses of 10-25 grays were delivered using 6-15-megaelectron volt electron beams to 1-5 IOERT fields. All patients also underwent EBRT and six received chemotherapy. Eight patients (73%) were alive and disease free at a median follow-up of 99 months (range, 37-126 months). All eight patients who underwent gross total resection were locally controlled. Three patients required surgical intervention for IOERT-rela...Continue Reading

Citations

Nov 1, 2005·International Journal of Radiation Oncology, Biology, Physics·Susanne OertelJuergen Debus
Mar 3, 2004·Surgical Oncology Clinics of North America·Donald A GoerDavid M Jablons
Mar 9, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·V ValentiniG Fiorentini
Oct 12, 2014·International Journal of Radiation Oncology, Biology, Physics·Michael R FolkertSuzanne L Wolden

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