Intraoperative High-Dose Dexamethasone in Cardiac Surgery and the Risk of Rethoracotomy

The Annals of Thoracic Surgery
Dirk van OschDexamethasone for Cardiac Surgery Study Group

Abstract

Cardiac surgery with the use of cardiopulmonary bypass is associated with a systemic inflammatory response. Intraoperative corticosteroids are administered to attenuate this inflammatory response. The recent Dexamethasone for Cardiac Surgery (DECS) trial could not demonstrate a beneficial effect of dexamethasone on major adverse events in cardiac surgical patients. Previous studies suggest that corticosteroids may affect postoperative coagulation and blood loss, and therefore could influence the risk of surgical reinterventions. We investigated the effects of prophylactic intraoperative dexamethasone treatment on the rate of rethoracotomy after cardiac surgery. We performed a post-hoc additional data collection and analysis in the DECS trial. A total of 4,494 adult patients undergoing cardiac surgery with cardiopulmonary bypass were randomly assigned to intravenous dexamethasone (1.0 mg/kg) or placebo. The primary endpoint for the present study was the incidence of any rethoracotomy within the first 30 postoperative days. Secondary endpoints included the reason for rethoracotomy and the incidence of perioperative transfusion of blood products. In the dexamethasone group, 217 patients (9.7%) underwent a rethoracotomy, and in the...Continue Reading

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Citations

May 11, 2018·Expert Review of Cardiovascular Therapy·Rachel WamboldtAdrian Baranchuk
Jan 19, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Shiyuan YuYi Li

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