PMID: 9524702Apr 3, 1998Paper

Intraoperative high dose rate brachytherapy in recurrent or metastatic colorectal carcinoma

Annals of Surgical Oncology
S NagE W Martin

Abstract

The survival of patients with recurrent or metastatic colorectal cancer usually is less than 12 months. In an attempt to improve this dismal prognosis, we investigated the role of intraoperative high dose rate brachytherapy (IOHDR) in the management of these patients. From April 1992 to December 1996, 26 patients with locally recurrent or metastatic colorectal carcinoma were treated with maximal surgical resection and IOHDR. Intraoperative radiation dose ranged from 10 to 20 Gy, prescribed at 0.5 cm depth. The residual tumor irradiated was microscopic in 16 patients (62%) and gross residual in 10 patients (38%). Six patients received postoperative external beam radiation therapy. After a median follow-up of 28 months (range 6 to 54 months), seven of 15 evaluable patients (47%) failed in the area treated with IOHDR. The median time to local failure was 21 months (range 4 to 52 months). The median survival was 23 months (microscopic 24 months; gross 17 months), with a 4-year actuarial survival rate of 36%. Major morbidity was observed in 7 patients (47%) and usually was surgery-related. The use of IOHDR in association with radical resection increases local control in patients with recurrent or metastatic colorectal cancer. Patien...Continue Reading

References

Mar 14, 1991·The New England Journal of Medicine·J E KrookJ A Mailliard
Oct 1, 1995·Journal of Surgical Oncology·H J WallaceH C Hoover
Aug 1, 1993·International Journal of Radiation Oncology, Biology, Physics·O AbuchaibeJ Alvarez-Cienfuegos

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Citations

Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Sanjay RainaMatthew B Podgorsak
Aug 5, 2000·International Journal of Radiation Oncology, Biology, Physics·K M AlektiarB D Minsky
Dec 31, 2003·International Journal of Radiation Oncology, Biology, Physics·Joost J NuyttensPeter C Levendag
Nov 7, 1998·International Journal of Radiation Oncology, Biology, Physics·R Martínez-MongeE W Martin
Mar 13, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Hohenberger
Apr 3, 1998·Annals of Surgical Oncology·R W Beart, O E Streeter

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