Intraoperative intraluminal injection of N-acetylcysteine allowing treatment of distal intestinal obstruction syndrome without the need for enterotomy

BMJ Case Reports
Nicholas Js Chilvers, James Wheeler

Abstract

We describe a case of an 18-year-old man who suffers from cystic fibrosis and developed distal intestinal obstruction syndrome while being treated as an inpatient. Following failed medical management, we proceeded to laparotomy where the small bowel was decompressed with retrograde milking into the stomach, leaving a section of impacted stool in the distal ileum. N-acetylcysteine was injected into the bowel lumen proximal to the obstruction. This resulted in dissolution of the stool without the need for enterotomy and is, to our knowledge, the first successful example of this technique in the literature.

References

Oct 1, 1990·Journal of Pediatric Gastroenterology and Nutrition·H O AndersenK Overgaard
Nov 5, 1999·Journal of Pediatric Surgery·R K MinkesE N Mendeloff
Feb 9, 2005·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·I J CliftonS P Conway
Jun 19, 2008·Archives of Surgery·Karen Speck, Anthony Charles
Jun 16, 2009·Journal of Pediatric Gastroenterology and Nutrition·Roderick H HouwenUNKNOWN ESPGHAN Cystic Fibrosis Working Group
Jun 18, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Carla ColomboUNKNOWN ECFS
Jun 9, 2012·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Travis AbichtMichael Moncure
Feb 18, 2014·Journal of Pediatric Surgery·Paul J FarrellyColin T Baillie
Jul 19, 2016·Paediatric Respiratory Reviews·Tyler GrovesDominic A Fitzgerald

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Citations

Jul 3, 2021·Antioxidants·Micaely Cristina Dos Santos TenórioMarília Oliveira Fonseca Goulart

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