PMID: 8127987Dec 1, 1993Paper

Intraoperative irradiation of the canine pancreas: short-term effects

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
H J HeijmansH J Hoekstra

Abstract

Intraoperative electron beam radiotherapy (IORT) is clinically used as a potential adjunctive treatment to surgery of locally advanced pancreatic and gastric cancer. The tolerance of the pancreas to IORT was studied in 15 adult beagles, divided in 3 groups of 5 beagles in which 25, 30 or 35 Gy IORT was delivered through a 6-7 cm circular lucite cone with 6-8 MeV electrons to the pancreas and medial wall of the duodenum. The dogs were followed for endocrine and exocrine pancreatic insufficiency. Two dogs (13%) developed radiation-induced morbidity which consisted of a common bile duct stenosis and an enterocolic fistula, as was confirmed at autopsy after 8 and 18 months, respectively. After a follow-up of 1 year, none of the dogs had developed pancreatitis, diabetes or exocrine insufficiency. There was a significant reduction in serum insulin levels and glucose clearance rates without overt diabetes for 30 Gy and 35 Gy (p < 0.05). No significant changes were found for 25 Gy. This study suggests that 25 Gy IORT to the pancreas may be used clinically, and that higher IORT doses may induce endocrine pancreatic insufficiency in the long-term.

References

Nov 1, 1976·Annals of Surgery·P L PieroniB J Rybak
Jun 1, 1988·International Journal of Radiation Oncology, Biology, Physics·F Ahmadu-SukaC E Whiteman
Aug 1, 1987·World Journal of Surgery·M AbeT Inamoto
Dec 1, 1986·American Journal of Clinical Oncology·W F SindelarT J Kinsella
Jan 1, 1993·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·H J HeijmansH J Hoekstra

Citations

Mar 2, 2002·International Journal of Radiation Oncology, Biology, Physics·Eckehard HorstN Willich
Apr 17, 2010·International Journal of Radiation Oncology, Biology, Physics·Lurong ZhangP Okunieff
Dec 29, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jerzy WydmanskiBarbara Maslyk
May 8, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Cengiz GemiciMihriban Kocak

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