Intraoperative ketorolac has an opioid-sparing effect in women after diagnostic laparoscopy but not after laparoscopic tubal ligation

Anesthesia and Analgesia
C R GreenM A Schork

Abstract

Ketorolac tromethamine (Toradol) is a parenteral, nonsteroidal antiinflammatory drug that is being extensively used to provide postoperative analgesia. This study evaluated whether intraoperative ketorolac would act synergistically with fentanyl to decrease postoperative analgesic requirements in outpatients undergoing gynecologic procedures. The patients studied were adult ASA physical status I or II females scheduled for diagnostic laparoscopy (DL) (n = 80) or laparoscopic tubal ligation (TL) (n = 46). Each patient received fentanyl 2 micrograms/kg intravenously (i.v.) before induction, followed by a standardized propofol anesthetic and 2 mL of saline or ketorolac 60 mg i.v. in a randomized double-blind fashion 30 min before the anticipated end of the operative procedure. Patients were assessed for postoperative pain via a 10-cm visual analog scale (VAS) (0 = no pain; 10 = severe pain) before analgesic treatment in the postanesthesia care unit (PACU). Severe postoperative pain (VAS or 5 or more) was treated with incremental doses of fentanyl, 25-50 micrograms i.v. by a blinded PACU nurse. Ibuprofen or acetaminophen with codeine was administered for pain control once the patient tolerated oral medications. This study showed th...Continue Reading

References

Jul 1, 1992·British Journal of Anaesthesia·J KinsellaG N Kenny
Apr 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·V K ComfortR W Yip
Dec 1, 1989·JAMA : the Journal of the American Medical Association·B S GoldJ M Neuhaus
May 1, 1987·Clinical Pharmacology and Therapeutics·D A O'HaraD Pemberton
Feb 1, 1994·Anaesthesia and Intensive Care·M H Shapiro, B L Duffy
Nov 1, 1993·The Australian & New Zealand Journal of Obstetrics & Gynaecology·J MonagleW Shearer
Jan 1, 1993·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·D A McGuireS D Hendricks
Aug 1, 1993·Anesthesia and Analgesia·Y DingP F White

❮ Previous
Next ❯

Citations

Jun 3, 1999·The Surgical Clinics of North America·D Tong, F Chung
Mar 14, 2001·Anesthesiology Clinics of North America·I Smith
Jul 17, 1998·Journal of Clinical Anesthesia·E M Tarazi, B K Philip
Aug 19, 2003·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Shari Laurion, Susan Jane Fetzer
Mar 16, 2000·The British Journal of Surgery·V L Wills, D R Hunt
Apr 8, 2003·Drugs·Allan B Shang, Tong J Gan
Oct 30, 2013·Alcoholism, Clinical and Experimental Research·Melissa A CydersDavid A Kareken
Mar 20, 1999·Obstetrics and Gynecology Clinics of North America·R M Ryder, M C Vaughan
Oct 16, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Neal Stuart GersteinPeter Mark Schulman
May 27, 2003·Anesthesiology·Charles B BerdeSrinivasa N Raja
Apr 23, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·A Macario, A G Lipman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.