Intraoperative microrecordings in the posterior hypothalamus of anaesthetized humans with aggressive behaviour.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Roberto CordellaGiovanni Broggi

Abstract

Two patients with uncontrollable aggressive behaviour underwent the placement of stimulating leads in the posterior hypothalamus (pHyp). One patient had also multifocal refractory epilepsy. Microrecordings were obtained in both patients during surgery under general anaesthesia. Firing rate, interspike intervals and oscillatory discharge patterns were analysed in 14 neurons. A mean discharge rate of 19 Hz, and oscillatory activity at 7-8 Hz were recorded in the first patient with aggressiveness and epilepsy. In the second patient the mean firing rate was 10 Hz, with evidence of both tonic and random firing patterns. Previous studies in patients with cluster headache showed that a discharge rate around 20 Hz and lack of a specific rhythmic pattern were the most consistent characteristics of neuronal discharge in this area. Our present findings therefore would suggest that the pattern of discharge of neurons in the pHyp should be evaluated with reference to the presence of concurrent pathology.

References

Dec 1, 1970·Journal of Neurosurgery·K SanoB Ishijima
Feb 4, 2005·Brain : a Journal of Neurology·J SchoenenA Maertens de Noordhout
Jul 2, 2005·Stereotactic and Functional Neurosurgery·Angelo FranziniGiovanni Broggi
Apr 28, 2007·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·R CordellaA Albanese
Feb 8, 2008·Cephalalgia : an International Journal of Headache·T BartschJ K Krauss
Mar 3, 2009·Neurosurgery·Sepehr SaniPhilip A Starr

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