Intraoperative milrinone versus dobutamine in cardiac surgery patients: a retrospective cohort study on mortality

Critical Care : the Official Journal of the Critical Care Forum
Dorthe Viemose NielsenCarl-Johan Jakobsen

Abstract

Several choices of inotropic therapy are available and used in relation to cardiac surgery. Comparisons are necessary to select optimal therapy. In Denmark, dobutamine and milrinone are the two inotropic agents most commonly used to treat post-bypass low cardiac output syndrome. This study compares all-cause mortality with these drugs. In a retrospective observational study we investigated 10,700 consecutive patients undergoing cardiac surgery from 1 April 2006 to 31 December 2013 at Aarhus and Aalborg University Hospitals in the Central and Northern Denmark Region. Prospectively entered data in the Western Danish Heart Registry on intraoperative use of inotropes were used to identify 952 patients treated with milrinone, 418 patients treated with dobutamine, and 82 patients receiving a combination of the two inotropes. All-cause mortality among patients receiving dobutamine was compared to all-cause mortality among milrinone receivers. Multiple logistic regression analyses including preoperative and intraoperative variables along with g-formula analyses were used to model 30-day and 1-year mortality risks. Reported were standardized mortality risk differences between the treatment groups. Among patients receiving intraoperative...Continue Reading

References

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Citations

Nov 30, 2018·Journal of Cardiovascular Pharmacology·Antoine HerpainFabio Sangalli
Mar 20, 2019·Interactive Cardiovascular and Thoracic Surgery·Jens K SkovCarl-Johan Jakobsen
Feb 25, 2020·Journal of Cardiovascular Pharmacology·Julie KellyKenneth Lupi
Sep 15, 2020·Annals of the American Thoracic Society·Emily A VailHannah Wunsch
Dec 24, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Debabrata BandyopadhyayMarc Humbert

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

R

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