PMID: 9546248Apr 18, 1998Paper

Intraoperative monitoring of danaparoid sodium anticoagulation during cardiovascular operations

Journal of Vascular Surgery
S D GitlinA H Schmaier

Abstract

Patients with cardiovascular disorders frequently need anticoagulation for diagnostic studies, surgical procedures, and therapy. Heparin-induced thrombocytopenia is a relatively common complication of heparin therapy that can result in thrombosis and subsequent limb loss or death, necessitating use of alternative anticoagulants. Two patients who needed cardiac surgery had thrombocytopenia induced by exposure to heparin and heparin-coated tubing. Several assays were examined for their ability to monitor intraoperative anticoagulation of a factor Xa inhibitor, danaparoid sodium. In vitro, celite and kaolin activated dotting times and activated partial thromboplastin time were prolonged linearly in the presence of increasing concentrations of danaparoid sodium. Aprotinin did not alter the linearity of the response but did alter its slope. In vivo, activated clotting times and activated partial thromboplastin time were insensitive to clinically significant changes in danaparoid sodium plasma levels during cardiopulmonary bypass. Correction in activated partial thromboplastin time lagged 2 hours behind clinically important changes in anti-factor Xa levels. Only anti-factor Xa levels were adequate to monitor intraoperative danaparoid...Continue Reading

References

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Citations

Oct 22, 2008·Journal of Thrombosis and Thrombolysis·Maryam Yavari, Richard C Becker
Feb 7, 2014·Science Translational Medicine·Alvin H Schmaier
Aug 18, 2005·Seminars in Thoracic and Cardiovascular Surgery·Friedrich-Christian Riess
Feb 10, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Glenn S Murphy, Jesse H Marymont
Nov 3, 2012·British Journal of Haematology·Mike MakrisUNKNOWN British Committee for Standards in Haematology
Nov 18, 2000·The Annals of Thoracic Surgery·J W Frederiksen
Aug 7, 2003·The Annals of Thoracic Surgery·Theodore E Warkentin, Andreas Greinacher
Nov 30, 1999·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·R R DaviesR J Gusberg
Mar 25, 2016·World Journal of Transplantation·Volker Assfalg, Norbert Hüser
Mar 20, 2008·Anesthesia and Analgesia·Christian BauerJean-Jacques Lehot
Jun 19, 2004·International Anesthesiology Clinics·Mark E Comunale, Elizabeth M Van Cott
Dec 12, 2003·The Annals of Thoracic Surgery·Theodore E Warkentin, Andreas Greinacher
Oct 10, 2001·Clinics in Chest Medicine·P F FedulloL J Rubin

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