Intraoperative radiation therapy (IORT) for soft tissue sarcoma - ESTRO IORT Task Force/ACROP recommendations.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Falk RoederCarlos Ferrer Albiach

Abstract

To describe guidelines for the use of intraoperative radiation therapy (IORT) in the treatment of soft-tissue sarcomas (STS). A panel of experts in the field performed a systematic literature review, supplemented their clinical experience and developed recommendations for the use of IORT in the treatment of STS. Based on the evidence from the systematic literature review and the clinical experience of the panel members, recommendations regarding patient selection, incorporation into multimodal treatment concepts and the IORT procedure itself are made. The rationale for IORT in extremity and retroperitoneal STS is summarized and results of the major series in terms of patient and treatment characteristics, oncological outcome and toxicity are presented. We define surgical factors, volumes for irradiation, technical requirements, dose prescription, recording and reporting, treatment delivery and care during the course of IORT covering the main IORT techniques used for the treatment of STS. In extremity STS, evidence originates from a few small prospective and mainly from retrospective single centre studies. Based on those reports, IORT containing-approaches result in very high local control rates with low rates of acute and late ...Continue Reading

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Citations

Sep 28, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R L Haas, A Gronchi
Jan 29, 2021·Critical Reviews in Oncology/hematology·Alba FiorentinoVittorio Donato
Oct 26, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·F RoederP Poortmans
May 7, 2021·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Silvia CammelliAlessio G Morganti
Nov 16, 2021·The Journal of Bone and Joint Surgery. American Volume·Jacob Bickels, Martin M Malawer

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