Intraoperative radiotherapy for recurrent and/or residual colorectal cancer

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
F A CalvoJ Voltas

Abstract

Intraoperative radiotherapy (IORT) is an attractive boosting modality in the combined treatment of recurrent and/or residual colorectal cancer. Twenty seven patients treated with IORT are analysed. Residual disease following resection of the primary tumor was treated in 11 cases (group I). Localized recurrent disease without previous radiotherapy was treated in 11 cases (group II). IORT was used in five additional patients with local recurrences in previously irradiated areas (group III). The treatment program consisted of maximal tumor resection, IORT (10-30 Gy) to the area of residual disease and external beam radiotherapy (46-50 Gy). The median follow-up time for the entire series of patients is 11 months. Local tumor control rates are 90% in group I, 63% in group II and 60% in group III. Toxicity and complications related to IORT observed in this initial experience have been pelvic pain (29%) and lower extremity neuropathy (3%). These early clinical results suggest that the IORT combined with surgery and external beam radiotherapy is feasible in primary and recurrent disease. Local control rates obtained in patients not suitable for curative surgery are encouraging.

References

Nov 1, 1987·Journal of Surgical Oncology·H J HoekstraJ Oldhoff
Sep 1, 1986·International Journal of Radiation Oncology, Biology, Physics·J E TepperJ K Martin
Oct 1, 1984·International Journal of Radiation Oncology, Biology, Physics·M Abe
Nov 1, 1982·Annals of Surgery·W F SindelarR Terrill
Jul 1, 1981·International Journal of Radiation Oncology, Biology, Physics·M Abe, M Takahashi
Oct 1, 1980·Diseases of the Colon and Rectum·A M CohenW C Wood

❮ Previous
Next ❯

Citations

May 1, 1991·Seminars in Surgical Oncology·S Nag
Jun 8, 2001·Diseases of the Colon and Rectum·G H MannaertsT Wiggers
Apr 9, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Felipe A CalvoRafael Herranz
Oct 23, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K M TveitK E Giercksky
Nov 7, 2002·International Journal of Radiation Oncology, Biology, Physics·Guido H H MannaertsTheo Wiggers
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·G H MannaertsH J Rutten
Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·W De NeveJ G Ribot
Mar 1, 1991·International Journal of Radiation Oncology, Biology, Physics·B E PowersS J Withrow
Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·J BiertJ Hoogenhout
Jun 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·B D MinskyL Harrison
Jan 1, 1994·The British Journal of Surgery·A M Abulafi, N S Williams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
S L GilletteS J Withrow
The Tohoku Journal of Experimental Medicine
H AsakawaK Nemoto
Journal of Surgical Oncology
S E Wilson, E Passaro
International Journal of Radiation Oncology, Biology, Physics
O AbuchaibeJ Alvarez-Cienfuegos
© 2022 Meta ULC. All rights reserved