Intraoperative radiotherapy in early breast cancer

The British Journal of Surgery
Emanuela EspositoMichael Douek

Abstract

Intraoperative radiotherapy (IORT) constitutes a paradigm shift from the conventional 3-5 weeks of whole-breast external beam radiotherapy (EBRT). IORT enables delivery of radiation at the time of excision of the breast tumour, targeting the area at highest risk of recurrence, while minimizing excessive radiation exposure to healthy breast tissue. The rationale for IORT is based on the observation that over 90 per cent of local recurrences after breast-conserving surgery occur at or near the original operation site. This article reviews trials of IORT delivered with different techniques and devices. IORT is a very attractive option for delivering radiotherapy, reducing the traditional fractionated treatment to a single fraction administered at the time of surgery. IORT has been shown to be associated with reduced toxicity and has several potential benefits over EBRT. Only two randomized clinical trials have been published to date. The TARGIT-A and ELIOT trials have demonstrated that IORT is associated with a low rate of local recurrence, although higher than that after EBRT (TARGIT-A: 3·3 versus 1·3 per cent respectively, P = 0·042; ELIOT: 4·4 versus 0·4 per cent, P < 0·001). However, the local recurrence rate for IORT fell wit...Continue Reading

References

Dec 25, 1991·JAMA : the Journal of the American Medical Association·D A LazovichR E Moe
Jun 1, 1982·International Journal of Radiation Oncology, Biology, Physics·R M ClarkW D MacDonald
Jun 3, 1993·The New England Journal of Medicine·U VeronesiT Savio
Oct 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T SaphnerR Gray
Feb 3, 2000·Journal of the National Cancer Institute·W F AthasC R Key
Jan 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Kathy L BaglanFrank A Vicini
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jenny HuangWilliam J Mackillop
Feb 27, 2003·The Breast Journal·Umberto VeronesiVirgilio Sacchini
Jul 9, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Philip PoortmansUNKNOWN EORTC Radiotherapy and Breast Cancer Groups
Feb 5, 2005·Breast Cancer Research and Treatment·Ismail JatoiSusan G Hilsenbeck
Feb 22, 2005·American Journal of Surgery·Tara L Huston, Rache M Simmons
Apr 6, 2005·Seminars in Radiation Oncology·Roberto Orecchia, Umberto Veronesi
Oct 21, 2006·Clinical Oncology : a Journal of the Royal College of Radiologists·C ColesUNKNOWN IMPORT Trials Management Group
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry BartelinkLaurence Collette
May 27, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mariella Mannino, John R Yarnold
Aug 12, 2008·The British Journal of Surgery·V SacchiniB McCormick
Aug 13, 2008·International Seminars in Surgical Oncology : ISSO·Robert M KirbyNatarajan Manimaran
May 8, 2009·Expert Review of Medical Devices·Adam DicklerDavid Wazer
Jun 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Benjamin D SmithJay R Harris
Jul 28, 2009·Journal of the American College of Surgeons·Benjamin D SmithJay R Harris
Sep 18, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Giovanni PaganelliUmberto Veronesi
Feb 12, 2010·The New England Journal of Medicine·Timothy J WhelanCarolyn Freeman
Oct 5, 2010·Lancet·Roland ReitsamerFelix Sedlmayer
Oct 5, 2010·Lancet·Benjamin D SmithHenry M Kuerer
Oct 6, 2010·Radiation Oncology·Christopher F NjehChristian M Langton
Oct 19, 2010·International Journal of Radiation Oncology, Biology, Physics·Jayant S VaidyaDavid Joseph
Nov 10, 2010·Nature Reviews. Clinical Oncology·Rajiv Sarin
Jul 15, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·UNKNOWN FAST Trialists groupJohn R Yarnold
May 1, 2012·International Journal of Radiation Oncology, Biology, Physics·Sergio MalutaCarlo Cavedon
Sep 18, 2012·International Journal of Radiation Oncology, Biology, Physics·Qi LiuCarsten Herskind
Dec 12, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Maria Cristina LeonardiRoberto Orecchia
Mar 26, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R W BlameyS E Pinder

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Citations

Oct 11, 2017·The Medical Journal of Australia·John Boyages
Jun 4, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Constanze ElfgenC J Tausch
May 26, 2021·Clinical Breast Cancer·Dana L CaseyDavid W Ollila
Jul 15, 2021·Clinical Breast Cancer·Nunzia Luna Valentina CernuscoRenzo Mazzarotto

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