PMID: 8943174Jan 1, 1997Paper

Intraoperative secretion of intact parathyroid hormone and amino-terminal parathyroid hormone fragments from normal parathyroid glands associated with solitary parathyroid adenoma

World Journal of Surgery
A Bergenfelz, B Ahrén

Abstract

The nonadenomatous parathyroid glands associated with parathyroid adenoma in patients with primary hyperparathyroidism (pHPT) are assumed to exhibit suppressed secretion of parathyroid hormone (PTH). Because the function of these glands is of clinical importance for calcium homeostasis after surgery for pHPT, we studied the decrease of serum levels associated with intact PTH (i-PTH) and amino-terminal PTH (N-PTH) after excision of a parathyroid adenoma. Blood samples were obtained from the cubital vein and the inferior thyroid vein in six patients with pHPT. The results show that the levels of both i-PTH and N-PTH decreased after removal of the parathyroid adenoma (p < 0.05 for both). Because the reduction was more pronounced for i-PTH than for N-PTH, the N/i ratio increased from 0.54 +/- 0.33 to 3.76 +/- 1.62 (p < 0.05). Furthermore, the levels of i-PTH and N-PTH were higher centrally than peripherally both before and after adenoma excision (p < 0.05). The results therefore suggest that the secretion of i-PTH and N-PTH in the remaining normal-size parathyroid glands is not completely suppressed. Furthermore, in these parathyroid glands the secretion of amino-terminal PTH fragments is relatively predominant when compared to the...Continue Reading

Citations

Sep 24, 1999·Annals of Surgery·F D MooreM Tanasijevic
Apr 22, 2010·Expert Review of Respiratory Medicine·Anna C C CarvalhoDaniela M Cirillo
Nov 17, 2010·Mathematical Biosciences and Engineering : MBE·Gigi Thomas, Edward M Lungu
Dec 14, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeffrey T ParsonsCatherine Holder
Jun 19, 2001·Alcoholism, Clinical and Experimental Research·J E ShellitoJ Kolls
Apr 6, 2001·Alcoholism, Clinical and Experimental Research·J A SalernoN P Cianciotto
May 20, 2005·Orthopaedic Nursing·Sunghee H Tak, Song Hee Hong
May 14, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Monica E ReyesMatthew B Schabath
Oct 22, 2003·Archives of Pathology & Laboratory Medicine·Alexis Byrne Carter, Peter J Howanitz

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