Intraoperative Sentinel Node Mapping in the Colon: Potential and Pitfalls

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Andrew C Currie

Abstract

Sentinel lymph node mapping (SLNM) may play a significant role in future delivery of colon cancer surgery because of an increase in early-stage, node-negative disease due to national bowel cancer screening programmes. Traditionally, colon lymphatic drainage has not been thought relevant as the operative approach cannot be tailored. Recent advances in local and endoscopic risk-reducing interventions for colonic malignancy have caused a rethink in approach. SLNM was initially attempted with blue dye techniques with limited success. Technological improvement has allowed surgeons to use near-infrared (NIR) light and NIR active tracers such as indocyanine green. This review provides an overview of the current status of intraoperative lymph node mapping in the colon, identifies challenges to the delivery of the techniques, and discusses potential solutions that may help SLNM play a role in improving the delivery of surgical care for patients with colon cancer.

References

Jan 1, 1991·Gastrointestinal Endoscopy·S I ParkR E Weesner
Dec 1, 1987·Diseases of the Colon and Rectum·T BjerkesetO Søreide
Feb 20, 2002·Diseases of the Colon and Rectum·Riccardo NascimbeniDirk R Larson
Oct 23, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Z RadovanovicD Radovanovic
Sep 19, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rocco RicciardiNancy N Baxter
Apr 27, 2007·World Journal of Surgery·Gaëtan Des GuetzGérard Perret
May 25, 2007·Annals of Surgery·Andreas E BembenekPeter M Schlag
Nov 7, 2007·Annals of Surgical Oncology·Sherry J LimGeorge J Chang
Apr 30, 2008·Surgical Endoscopy·Norikatsu MiyoshiShingi Imaoka
Oct 7, 2008·Surgical Oncology·R A CahillJ Marescaux
Dec 25, 2008·Annals of Surgery·Yusuke TajimaMitsuo Kusano
Feb 19, 2009·The British Journal of Surgery·S P BachUNKNOWN Association of Coloproctology of Great Britain and Ireland Transanal Endoscopic Microsurgery (TEM) Collaboration
May 28, 2009·Annals of Surgical Oncology·Ronan A CahillPeter M Schlag
Jan 27, 2010·American Journal of Clinical Oncology·Peter KornpratCord Langner
May 11, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W KelderK Yanaga
May 10, 2011·The Lancet Oncology·Martijn Hgm van der PasWilhelmus J H J Meijerink
Mar 13, 2013·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Martijn H G M van der PasWilhelmus J H J Meijerink
Mar 25, 2015·Annals of Surgical Oncology·Naoto NishigoriYoshiyuki Nakajima
Jun 26, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Nynke S van den BergFijs W B van Leeuwen
Sep 16, 2016·Anticancer Research·Gabriel LiberaleUNKNOWN R&D Group for the Clinical Application of Fluorescence Imaging at the Jules Bordet Institute
Sep 19, 2017·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A C CurrieR H Kennedy
Mar 20, 2018·Techniques in Coloproctology·M ChandR Cohen

❮ Previous
Next ❯

Citations

Mar 7, 2020·Diseases of the Colon and Rectum·Conor P Delaney

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.