Intraoperative Use of Vasopressors Is Safe in Head and Neck Free Tissue Transfer

Journal of Reconstructive Microsurgery
Edward W SwansonJustin M Sacks

Abstract

The purpose of this study is to identify whether intraoperative use of vasoactive medications increases the risk of free flap failure or complications through a systematic review and meta-analysis. PubMed/MEDLINE, EMBASE, and Scopus databases were searched for studies published through January 2015. English publications that met the following criteria were included: (1) adult patients undergoing head and neck free flap reconstruction; (2) comparison of patients with and without intraoperative vasopressor administration; and (3) documentation of flap failure rate and/or flap complications. The primary outcome was the incidence of flap failure. The secondary outcome was the incidence of overall flap complications. Meta-analysis was performed to obtain pooled odds ratios (ORs) of the effect of intraoperative use of vasopressors on flap failure and complication rates. Four cohort studies met inclusion criteria. All studies were of high methodological quality with an average Methodological Index for Non-Randomized Studies score of 18.75 (range 16-23). A total of 933 patients undergoing head and neck free flap reconstruction were included. Meta-analysis demonstrated no statistically significant difference in the incidence of flap fai...Continue Reading

Citations

Oct 1, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jan MácaMichal Holub
Aug 3, 2017·Der Anaesthesist·A RandM Bauer
Jul 10, 2019·Head & Neck·Marianne AbouyaredJason M Leibowitz
Mar 13, 2019·Plastic and Reconstructive Surgery. Global Open·Jill P StoneGedge D Rosson
Nov 11, 2020·Microsurgery·Robert J TaylorTerry A Day
Nov 26, 2020·Plastic and Reconstructive Surgery·Erin BrownJoon Pio Hong
Feb 23, 2021·Craniomaxillofacial Trauma & Reconstruction·Anthony MassaroRui Fernandes

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