Intraoperative values of S-100 protein, myelin basic protein, lactate, and albumin in the CSF and serum of neurosurgical patients

Journal of Neurology, Neurosurgery, and Psychiatry
J De VriesK J B Lamers

Abstract

To assess the concentrations of S-100 protein, myelin basic protein (MBP), and lactate, and the (CSF)/serum albumin ratio (Qalb) during intracranial neurosurgical procedures. Samples of CSF from 91 patients with various CNS diseases were obtained by aspiration of cisternal CSF at the beginning of surgery (before starting surgical manipulation of the brain) and concentrations of S-100 protein, MBP, and lactate, and Qalb were determined. At the same time blood was sampled for determination of serum S-100 protein concentration. Patients were divided into three groups according to the aetiology of their CNS disease (intracranial haemorrhage, n=11; benign intracranial mass lesion, n=52; malignant neoplastic disease, n=28). Radiological and intraoperative characteristics were documented. In each of these three groups median values of all four CSF variables measured were raised. The occurrence of brain oedema and a midline shift correlated significantly with raised concentrations of MBP and Qalb. Breaching of the arachnoid layer, documented at surgery for benign lesions, correlated with higher concentrations of MBP, lactate, CSF S-100 protein, and Qalb. Intraoperative values of S-100 protein, MBP, lactate, and Qalb are increased in pa...Continue Reading

References

May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·N H SternbergerH D Webster
Apr 1, 1987·Journal of the Neurological Sciences·T SiegalO Abramsky
Dec 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·C J SindicP L Masson
Jul 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·T IngebrigtsenB Langbakk
Oct 1, 1996·British Journal of Neurosurgery·S A RossB J Rowlands
May 1, 1997·Dementia and Geriatric Cognitive Disorders·P T NooijenK J Lamers
Nov 6, 1998·Stroke; a Journal of Cerebral Circulation·P MartensP Johnsson

❮ Previous
Next ❯

Citations

Aug 24, 2004·Der Anaesthesist·M FriesR Kuhlen
Sep 23, 2003·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Britt-Marie StålnackePeter Sojka
Jul 23, 2005·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Pierre LescuyerJean-Charles Sanchez
Sep 11, 2014·Neural Regeneration Research·Xue YaoYanshu Zhang
Mar 20, 2003·Microscopy Research and Technique·T Gonzalez-MartinezJ A Vega
Mar 23, 2007·Acta Neurologica Scandinavica·R AnckarsäterH Anckarsäter
Jul 14, 2009·NMR in Biomedicine·Eva KolwijckRon A Wevers
Oct 1, 2015·BioMed Research International·Lenka HajdukováInka Matuchová
Oct 20, 2015·Journal of the Neurological Sciences·Franc LlorensInga Zerr
Mar 14, 2018·Journal of Veterinary Emergency and Critical Care·Patricia G RosensteinDez Hughes
Jan 10, 2020·Acta neurochirurgica·Norbert WąsikRoman Jankowski

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.