Intraoperatively measured tumor size and frozen section results should be considered jointly to predict the final pathology for lung adenocarcinoma

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Erjia ZhuChang Chen

Abstract

Invasive adenocarcinoma intraoperatively misdiagnosed as adenocarcinoma in situ or minimally invasive adenocarcinoma is more likely to undergo potentially insufficient resection. The purpose of our study was to evaluate the diagnostic accuracy of frozen section. We retrospectively reviewed 1,111 lung adenocarcinomas from January to March 2016 to evaluate the diagnostic performance of frozen section. A derivation cohort consisting of 436 cases of adenocarcinoma in situ or minimally invasive adenocarcinoma diagnosed by frozen section in the same period were analyzed to find predictive factors for invasive adenocarcinoma as the final diagnosis. Validation cohorts (first: April to June 2016, second: January to March 2015) were included to confirm the results. The overall concordance rate between frozen section and final diagnosis was 92%. Most frozen section errors were underestimation. The sensitivity of frozen section diagnosis for minimally invasive adenocarcinoma (74%) was significantly lower than others. Intraoperatively measured tumor size was the only independent factor for invasive adenocarcinoma as the final diagnosis (<1 cm: 2%, reference; 1-1.4 cm: 15%, odds ratio, 5.678; > 1.5 cm: 18%, odds ratio, 5.878; P = 0.001) in t...Continue Reading

References

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Citations

Nov 7, 2019·The Analyst·Tobias MeyerJürgen Popp
Oct 16, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Weiyan SunUNKNOWN Surgical Thoracic Alliance of Rising Star Group
Feb 6, 2021·The Journal of Thoracic and Cardiovascular Surgery·Zhen-Bin QiuWen-Zhao Zhong

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Methods Mentioned

BETA
biopsy
dissection

Software Mentioned

SPSS

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