Intraoral dissemination of treponemes after periodontal therapy

Clinical Oral Investigations
Benjamin EhmkeAnnette Moter

Abstract

Oral treponemes are related to chronic periodontitis, but the effect of periodontal therapy on the majority of treponemal species is unknown. The aim of this prospective study was to evaluate the dynamics in prevalence profiles of treponemes in different habitats of the oral cavity. Thirty-five patients with chronic periodontitis were randomly assigned to mechanical debridement alone (control group) or systemic amoxicillin/metronidazole plus chlorhexidine (test group). Subgingival and mucous membrane plaque samples were taken at baseline, after 10 days, and during supportive periodontal therapy at 3, 6, 9, 12, 18, and 24 months. T. denticola, T. lecithinolyticum, T. maltophilum, T. socranskii, T. vincentii, and treponemal phylotypes I-VII were detected using polymerase chain reaction (PCR) and dot blot analysis. For the majority of the assessed treponemes, a significant intragroup increase in prevalence in the different habitats ( P<0.05) occurred over the study course but, compared to debridement alone, adjunctive antimicrobial therapy resulted in a nonsignificant trend toward lower prevalence in the subgingival habitat. In no case were treponemes eradicated from the oral cavity. After both therapies, possibly new infection wi...Continue Reading

References

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Citations

Sep 8, 2007·Clinical Oral Investigations·María Cecilia Martínez-PabónSergio Iván Tobón-Arroyave
Feb 28, 2007·Infection and Immunity·Catherine A Brissette, Sheila A Lukehart
Mar 5, 2010·Journal of Dental Research·P GaibaniV Sambri
May 19, 2009·International Journal of Medical Microbiology : IJMM·Giuseppe ValenzaUlrich Vogel
Apr 28, 2005·Periodontology 2000·Richard P Ellen, Vaia B Galimanas
Nov 13, 2007·Veterinary Microbiology·Marcel NordhoffLothar H Wieler

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