Intraorbital Irrigation of Amphotericin B in the Treatment of Rhino-Orbital Mucormycosis

Ophthalmic Plastic and Reconstructive Surgery
Zachary P Joos, Bhupendra C K Patel

Abstract

The aim of this study was to describe a modified technique of intraorbital irrigation of amphotericin B in the treatment of rhino-orbital mucormycosis. A 38-year-old man was diagnosed with rhino-orbital mucormycosis and subsequently underwent orbital and sinus debridement with postoperative intraorbital irrigation of amphotericin B. Daily irrigation of amphotericin B was infused in the orbit with measures taken to avoid iatrogenic toxicity to the ocular surface and gastrointestinal tract. The use of local amphotericin B irrigation directly in the orbit allowed for local control of infection without orbital exenteration, a good cosmetic outcome and excellent postoperative visual acuity. The published reports on the use of intraorbital irrigation with amphotericin B in mucormycosis infections were reviewed and the technique used at the institution was outlined.

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Citations

Jul 7, 2016·Indian Journal of Ophthalmology·Bipasha MukherjeeMd Shahid Alam
May 16, 2017·Current Opinion in Ophthalmology·Evan Kalin-HajduRobert C Kersten
Dec 12, 2019·Eye·Allister S LeeTimothy J Sullivan
Mar 21, 2019·Ophthalmic Plastic and Reconstructive Surgery·Kristin E HirabayashiM Reza Vagefi
Aug 31, 2020·Orbit·Allison J ChenCatherine Y Liu
Sep 13, 2019·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Allister S Lee, Timothy J Sullivan
Feb 13, 2021·Case Reports in Infectious Diseases·Aleksandr KhudyakovMichael Rose
Jun 11, 2021·Ocular Immunology and Inflammation·Vazhipokkil Anju ChandranBipasha Mukherjee
Dec 14, 2019·Journal français d'ophtalmologie·A MartelG Poissonnet
Oct 14, 2021·Ocular Immunology and Inflammation·Mohamed Ashraf Eldesouky, Hazem A Elbedewy

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