Intraosseous malignant peripheral nerve sheath tumor (MPNST) of the thoracic spine: a rare cause of spinal cord compression

Spine
K K GnanalinghamKevin O'Neill

Abstract

To describe the management of a patient presenting with intraosseous MPNST of the thoracic spine causing cord compression. Malignant peripheral nerve sheath tumors (MPNST) are uncommon tumors of cells of peripheral nerve sheath origin. MPNST typically present as an enlarging mass originating from a peripheral nerve root in the trunk, extremities, and head and neck region. METHODS.: A 59-year-old woman presented with midthoracic back pain, paraparesis, and a T4 sensory level. Magnetic resonance image scan revealed a large enhancing and destructive lesion at the T3 level with cord compression. Decompressive laminectomies, tumor debulking, and instrumentation was performed from a posterior approach. At surgery, the lesion was noted to originate from the T3 vertebral body, and separate from the dura and spinal nerve roots. Surgical excision was incomplete and the spine was stabilized with a Ti frame. MPNST was confirmed histologically. Despite adjuvant radiotherapy, she developed metastatic deposits in the spine and femur. Intraosseous MPNST causing spinal cord compression has not been described as yet and should be added to the differential diagnosis of primary bone tumors causing cord compression. Prognosis with MPNST can be poor...Continue Reading

References

Aug 1, 1975·Journal of Neurology, Neurosurgery, and Psychiatry·C E Polkey
Apr 1, 1987·American Journal of Clinical Pathology·M R WickJ C Manivel
Oct 27, 1998·International Journal of Radiation Oncology, Biology, Physics·W W WongL L Gunderson
Nov 5, 1998·Neurosurgery·C J ChangS H Huang
Dec 22, 1999·Journal of Pediatric Hematology/oncology·M CasanovaF Fossati-Bellani
Feb 11, 2000·Toxicologic Pathology·P Kleihues, H Ohgaki

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Citations

Dec 6, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Bin ZhuFeng Wei
Jul 8, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Ruth PrietoFrancisco González-Llanos
Jan 2, 2014·Case Reports in Medicine·Leila MetouiSalah Othmani
Nov 20, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·V R Roopesh KumarSudheer Kumar Gundamaneni
Apr 5, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·James A StadlerSandi K Lam
Nov 7, 2009·Journal of Korean Neurosurgical Society·Seong-Cheol ParkHyun-Jib Kim
Jul 28, 2016·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Saravanaraja MuthusamyH Thomas Temple
Jan 8, 2021·Skeletal Radiology·Rupert BerkeleyAsif Saifuddin
Jun 17, 2011·The American Journal of Surgical Pathology·Cristiane M IdaKrishnan K Unni

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