Intraosseous Melanotic Schwannoma in the Sacrum Mimicking Primary Bone Tumor

NMC Case Report Journal
Yoshitaka NagashimaMasahito Hara

Abstract

Primary tumors of sacrum are rarely seen, and the differential diagnosis is extensive, such as chordomas, giant cell tumors, and schwannomas. Sacral intraosseous schwannomas (IOSs) are very rare and encompass approximately 1%-5% of all spinal schwannomas. Melanotic schwannomas (MSs) are categorized as an unusual variant of benign schwannomas; however, they sometimes follow a malignant course. The authors present a case of MS with intraosseous extension into sacrum in a 48-year-old male arising from the left S2 nerve root. Magnetic resonance imaging (MRI) and computed tomography (CT) scan demonstrated a destructive mass in the sacrum. He was made a diagnosis with MS by 18F-fluoro-deoxy-glucose positron-emission-tomography (18F-FDG PET) and open biopsy. The tumor was blackish-colored and vascular-rich fragile tumor covered by fibrous capsule. The floor of the tumor was not encapsulated and invading into the sacral bone. Total removal of the tumor together with the left S2 nerve of origin via posterior approach was achieved. The patient made dramatic recovery of neurological symptoms and tumor recurrence is not seen for 6-month follow-up period. MS is a benign tumor with potential for aggressive behavior and capacity to metastasiz...Continue Reading

References

Dec 1, 1992·Cancer·P S TurkH J Wanebo
Jul 14, 1999·The American Journal of Surgical Pathology·D J BratP C Burger
Sep 8, 2004·Neurosurgical Focus·Ho-Yeol ZhangDaniel H Kim
Sep 8, 2004·Neurosurgical Focus·Paul KlimoMeic H Schmidt
Nov 11, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Janet F EaryErnest U Conrad
Apr 26, 2012·Rare Tumors·Jason M HooverWilliam E Krauss
Sep 17, 2013·European Journal of Radiology·Ming-Jue SiWei-Bin Zhang
Oct 1, 2013·Neurologia Medico-chirurgica·Mário Henrique Girão FariaFeres Eduardo Chaddad-Neto
Apr 5, 2017·Journal of Pathology and Translational Medicine·Sung-Eun ChoiSe Hoon Kim
Apr 27, 2017·Oncotarget·Weibo PanZhaoming Ye
Aug 31, 2017·BioMed Research International·Yoshihiro MatsumotoYasuharu Nakashima

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Citations

May 6, 2021·Surgical Neurology International·Dallas J SoylandShawn M Vuong

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Methods Mentioned

BETA
biopsy
dissection

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