Intraovarian injection of autologous human mesenchymal stem cells increases estrogen production and reduces menopausal symptoms in women with premature ovarian failure: two case reports and a review of the literature

Journal of Medical Case Reports
Prosper IgboeliAyman Al-Hendy

Abstract

Premature ovarian failure is a relatively common condition that affects 1-3% of adult women. Premature ovarian failure occurs when there is loss of ovarian function in women younger than 40 years of age. The causes are mostly iatrogenic or idiopathic. Amenorrhea and infertility are the most important clinical manifestations. So far, no therapeutic intervention has been proved effective in restoring fertility in patients with premature ovarian failure. Attempts to stimulate ovarian function through hormone manipulation typically prove unsuccessful, and patients usually resort to egg donation to achieve pregnancy. In our preclinical work, intraovarian administration of human bone marrow-derived mesenchymal stem cells was able to restore ovarian hormone production, reactivate folliculogenesis, and reverse infertility in a chemotherapy-induced ovarian failure mouse model. We present two cases of Caucasian women with premature ovarian failure who resumed ovarian estrogen production and menses 7 months following autologous bone marrow-derived mesenchymal stem cell injections into the ovary. This pilot clinical study is registered with ClinicalTrials.gov (identifier NCT02696889 ). In this report, we present data from our first two cas...Continue Reading

Associated Clinical Trials

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Citations

Apr 10, 2021·Reproductive Sciences·P PetricM Stimpfel
May 28, 2021·Frontiers in Cell and Developmental Biology·Seung Joo ChonMee-Sup Yoon
Jul 3, 2021·Cells·Sarama SahaSham S Kakar
Jul 20, 2021·Advanced Drug Delivery Reviews·José das NevesBruno Sarmento
Apr 16, 2021·Endocrine Reviews·Valerie A FloresJoAnn E Manson

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Methods Mentioned

BETA
hormone replacement therapy
bone marrow aspiration

Clinical Trials Mentioned

NCT02696889

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