Intrapallidal dopamine restores motor deficits induced by 6-hydroxydopamine in the rat

Journal of Neural Transmission
A GalvanJorge Aceves

Abstract

To explore whether dopamine deficits in the globus pallidus have a role in generating the motor symptoms of Parkinson's disease, we examined the effects of selective intrapallidal administration of dopamine or its antagonists in rats unilaterally lesioned with 6-hydroxydopamine into the medial forebrain bundle. Either the turning behavior induced by apomorphine or the deficit in the performance of a skilled forelimb-reaching task was used as assay for drug action. Microinjection of either the D2 receptor antagonist, sulpiride, or the D1 receptor antagonist, SCH-23390, into the dopamine-denervated pallidum significantly reduced apomorphine induced turning. In animals trained to perform a skilled forelimb-reaching task, 6-OHDA lesions caused a marked motor deficit in the contralateral forelimb. Intrapallidal dopamine applied either intermittently or continuously, restored up to 50% of the motor performance. Continuous application promoted a motor recovery that outlasted dopamine administration. These results show that lack of dopamine in the GP plays an important role in generating the motor symptoms caused by lesion of dopaminergic pathways. Moreover, motor recovery was produced by selectively injecting dopamine into the globus ...Continue Reading

References

Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D M WeinerM R Brann
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R T FremeauM G Caron
Feb 1, 1991·Journal of Neuroscience Methods·C P MontoyaS B Dunnett
Jun 12, 1987·European Journal of Pharmacology·P BaroneT N Chase
Apr 1, 1972·European Journal of Pharmacology·B CostallJ E Olley
Nov 1, 1993·Journal of Chemical Neuroanatomy·C A FoxS J Watson
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A I LeveyB J Ciliax
Mar 21, 1996·Nature·D M GashG A Gerhardt
Dec 16, 1996·The Journal of Comparative Neurology·S J Shammah-LagnadoL Heimer
Apr 16, 1998·Histochemistry and Cell Biology·N E LazarovC Pilgrim
Aug 6, 1998·Neuroscience·D R SmithM Gallagher
May 27, 1999·Molecular and Chemical Neuropathology·K A Skau, C G Triplett
Jul 21, 1999·Neuroscience Research·M CossetteA Parent
Dec 14, 1999·Behavioural Brain Research·W Hauber, S Lutz

❮ Previous
Next ❯

Citations

May 5, 2005·Experimental Neurology·Thomas DebeirRita Raisman-Vozari
Mar 22, 2002·The European Journal of Neuroscience·Alessandro StefaniGiorgio Bernardi
Oct 31, 2002·Reviews in the Neurosciences·Arun Chander RamachandranIvar Marcelo Mendez
Nov 19, 2003·The European Journal of Neuroscience·Caroline JanChantal François
Jan 8, 2009·Annals of Neurology·Jose A ObesoC Warren Olanow
Aug 16, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Bettina C SchwabRichard J A van Wezel
Mar 31, 2016·Brain Structure & Function·Lara Eid, Martin Parent
Aug 27, 2005·Neurochemistry International·Holger FuchsWolfgang Hauber
Jan 31, 2003·Annals of Neurology·Alan L WhoneDavid J Brooks
Sep 1, 2015·Frontiers in Neuroanatomy·Lara Eid, Martin Parent
Dec 29, 2011·Neurobiology of Learning and Memory·Amanda A DiepRobert F Berman
May 27, 2014·Frontiers in Aging Neuroscience·Abdelhamid BenazzouzJonathan Chetrit
Feb 4, 2016·The European Journal of Neuroscience·Daniel J HegemanC Savio Chan
Aug 11, 2006·Journal of Neurophysiology·Adán HernándezJorge Aceves
Jun 20, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas Wichmann
Oct 25, 2020·The European Journal of Neuroscience·Israel Conde RojasBenjamín Florán

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.