Intraparaventricular neuropeptide Y and ghrelin induce learned behaviors that report food deprivation in rats

Neuroreport
David C JewettAllen S Levine

Abstract

Rats were trained to discriminate between 2 and 22-h food deprivation in a choice paradigm. During tests, 20 min of food consumption eliminated internal stimuli associated with 22-h food deprivation. In other tests, rats food-restricted for 2 h were given neuropeptide Y or ghrelin by administration into the paraventricular nucleus of the hypothalamus. Both neurochemicals induced effects similar to those following 22-h food restriction (increased behavior appropriate for 22-h deprivation). These findings suggest that internal stimuli produced by 22-h food deprivation are altered by food consumption and mimicked by feeding-inducing neurochemicals administered into a brain area associated with feeding regulation. Thus, hunger discrimination is a useful model to examine neurochemical and dietary factors that alter internal states associated with eating.

References

Jan 1, 1992·Pharmacology
Jun 1, 1992·Pharmacology, Biochemistry, and Behavior·D C JewettT Thompson
Oct 4, 1991·Brain Research·D C JewettA S Levine
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B G Stanley, S F Leibowitz
Feb 1, 1994·Pharmacology, Biochemistry, and Behavior·K J SchuhA S Levine
Feb 26, 1998·Pharmacology, Biochemistry, and Behavior·E O'HareA S Levine
Nov 1, 2000·Nature·M TschöpM L Heiman
May 25, 2002·The New England Journal of Medicine·David E CummingsJonathan Q Purnell

❮ Previous
Next ❯

Citations

Nov 23, 2007·Current Opinion in Pharmacology·Terry L DavidsonStephen C Benoit
May 31, 2011·Peptides·Karolina P Skibicka, Suzanne L Dickson
Apr 23, 2019·Annals of the New York Academy of Sciences·Raoni C Dos-SantosAndré S Mecawi
Jan 3, 2012·Endocrinology·Karolina P SkibickaSuzanne L Dickson
Jun 4, 2019·Frontiers in Endocrinology·Mitchell A HeadPawel K Olszewski
Jul 18, 2021·Current Biology : CB·Justin N SiemianYeka Aponte

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.