Intrapartum antibiotic exposure for group B Streptococcus treatment did not increase penicillin allergy in children

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Sara M MayMiguel A Park

Abstract

Group B Streptococcus (GBS) is the leading infectious cause of neonatal morbidity and mortality in the United States. Intrapartum administration of antibiotics to mothers with positivity to GBS is performed for prevention, with penicillin being the drug of choice. Previous studies have noted an increase in atopic diseases other than drug allergy associated with intrapartum antibiotic exposure. To determine whether intrapartum exposure to penicillin for GBS increases the likelihood of penicillin allergy in children. Retrospective chart review was performed for patients from a birth cohort. The birth cohort included children born in 2007 at a tertiary care hospital and had local addresses. Information on GBS status of the mother, intrapartum antibiotic exposure, delivery mode, and birth order was collected and analyzed. Of 927 children identified, 804 were included in the cohort. Eighty children (10%) had a reported penicillin allergy; most were white (79%) and boys (61%). Intrapartum exposure to penicillin (odds ratio 0.84, 95% confidence interval 0.45-1.57, P = .59) or to amoxicillin or ampicillin (odds ratio 0.22, 95% confidence interval 0.01-3.71, P = .29) did not increase the risk of penicillin allergy in children. In additi...Continue Reading

References

May 1, 1991·The Australian & New Zealand Journal of Obstetrics & Gynaecology·S M Garland, J R Fliegner
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Jan 9, 2015·Journal of the American Board of Family Medicine : JABFM·Debra L WohlKaitlyn Tyrie

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Citations

Jul 20, 2019·Pharmacy : Journal of Pharmacy, Education and Practice·Louis Lteif, Lea S Eiland

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