Intrapartum evidence of early-onset group B streptococcus

Obstetrics and Gynecology
Carmen M TudelaJeanne S Sheffield

Abstract

To estimate if neonates with early-onset group B streptococcus (GBS) sepsis have clinical evidence of fetal infection during labor or at delivery. Retrospective cohort study of all neonates diagnosed with GBS sepsis by culture and clinical findings within the first 72 hours of life from January 1, 2000, through December 31, 2008, at Parkland Health and Hospital System. Medical records were reviewed and maternal, neonatal, and delivery data were ascertained. These neonates then were compared with all neonates delivered during the same time period. During the study period, 143,384 live-born neonates were delivered at our institution; 94 were diagnosed with early-onset GBS sepsis. The majority of these neonates (n=93) were diagnosed with early-onset GBS within the first hour of life. Neonates with early-onset GBS sepsis had a significant increase in preterm delivery, cesarean delivery (total and for fetal distress), 1- and 5-minute Apgar scores of 3 or lower, umbilical cord pH less than 7.0, and a base deficit of 12 mmol/L or higher. In addition, nulliparity differed between those with early-onset GBS and those without (74% compared with 33%, P<.001) as did chorioamnionitis rates (62% compared with 8%, P<.001). We believe that the...Continue Reading

References

May 4, 2005·Pediatrics·Karen M PuopoloEric C Eichenwald
Nov 2, 2006·Obstetrics and Gynecology·UNKNOWN ACOG Committee on Obstetric Practice
May 8, 2008·JAMA : the Journal of the American Medical Association·Christina R PharesUNKNOWN Active Bacterial Core surveillance/Emerging Infections Program Network
Aug 16, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·L S PulverC L Byington
Jun 19, 2009·The New England Journal of Medicine·Melissa K Van DykeStephanie J Schrag
Jun 24, 2010·Clinics in Perinatology·Jennifer R Verani, Stephanie J Schrag

❮ Previous
Next ❯

Citations

Jul 9, 2013·Molecular Diagnosis & Therapy·Stéphane EmonetBegoña Martinez de Tejada
Nov 10, 2012·Seminars in Fetal & Neonatal Medicine·Evelyne Jacqz-AigrainJohn N van den Anker
Oct 6, 2012·Pediatric Clinics of North America·Evelyne Jacqz-AigrainJohn N van den Anker
Mar 2, 2016·American Journal of Obstetrics and Gynecology·Jessica SchollSteven S Witkin
Nov 9, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Neal J RussellCarol J Baker
Dec 26, 2018·American Journal of Reproductive Immunology : AJRI·Jessica A SuttonDavid M Aronoff
May 22, 2019·BMC Pregnancy and Childbirth·Kate ClouseNatasha Halasa
Feb 11, 2015·The Journal of Biological Chemistry·Chiara TonioloRobert Janulczyk
May 7, 2021·Obstetrics and Gynecology·Celeste BeckAlison D Gernand
Jan 1, 2016·Pediatrics·Jonathan M WorthamUNKNOWN Eunice Kennedy Shriver NICHD Neonatal Research Network

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.