PMID: 8971017Dec 1, 1996Paper

Intrapatient sequence variation of the gag gene of human immunodeficiency virus type 1 plasma virions

Journal of Virology
F K YoshimuraL Corey

Abstract

Because certain regions of the gag gene, such as p24, are highly conserved among human immunodeficiency virus (HIV) isolates, many therapeutic strategies have been directed at gag gene targets. Although intrapatient variation of segments of gag have been determined, little is known about the variability of the full-length gag gene for HIV isolated from a single individual. To evaluate intrapatient full-length gag variability, we derived the nucleotide sequences of at least 10 cDNA gag clones of virion RNA isolated from plasma for each of four asymptomatic HIV type 1-infected patients with relatively high CD4+ T-cell counts (300 to 450 cells per mm3). Mean values of intrapatient gag nucleotide variation obtained by pairwise comparisons ranged from 0.55 to 2.86%. For three subjects, this value was equivalent to that reported for intrapatient full-length env variation. The greatest range of intrapatient mean nucleotide variation for individual protein-coding regions was observed for p7. We did not detect any G-to-A hypermutation, as A-to-G and G-to-A transitions occurred at similar frequencies, accounting for 29 and 25%, respectively, of the changes. Mean variation values and phylogenetic analysis suggested that the extent of nucl...Continue Reading

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Citations

Oct 13, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·L M SkinnerM Katzman
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·M SrivastavaA Srinivasan
Jan 6, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·John R KoeppeCara C Wilson
Nov 5, 2002·Journal of Virology·Gerald H LearnLawrence Corey
Jun 17, 2014·Bioinformatics·Serghei MangulEleazar Eskin
Sep 15, 2001·Journal of Neuropathology and Experimental Neurology·J Torres-MuñozC K Petito
Nov 21, 2007·PLoS Pathogens·Anne PiantadosiJulie Overbaugh

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