Intrapericardial basic fibroblast growth factor induces myocardial angiogenesis in a rabbit model of chronic ischemia

American Heart Journal
C LandauC C Haudenschild

Abstract

The objective of this study was to determine whether basic fibroblast growth factor (bFGF), a known angiogenic factor, can promote new vessel growth when infused within the pericardial space in a model of chronic myocardial ischemia. Intravenous angiotensin II (AII) was infused to induce left ventricular hypertrophy and concomitant ischemia in New Zealand white rabbits. Basic FGF was infused into the intrapericardial space with an osmotic pump. Animals were assigned to one of four groups: group 1 received intrapericardial bFGF and intravenous AII, group 2 received intrapericardial bFGF and intravenous saline solution, group 3 received intrapericardial albumin and intravenous AII, and group 4 received intravenous AII only. Epicardial angiogenesis was graded histologically on a scale of 0 to 2. Animals receiving intravenous administration of AII displayed left ventricular hypertrophy that disproportionately affected the interventricular septum with a wall thickness of 5.62 +/- 1.00 mm versus 3.98 +/- 0.61 mm in the AII group and the saline solution control group, respectively (p < 0.005). A highly localized angiogenic effect of bFGF was observed. The mean angiogenesis scores were 1.9, 1.4, 1.3, and 0.2 (p < 0.001) with an angioge...Continue Reading

References

Jul 1, 1991·Circulation Research·S BanaiE F Unger
Sep 1, 1991·Biomaterials·E R EdelmanM Klagsbrun
May 1, 1987·Endocrine Reviews·D GospodarowiczG Neufeld
Sep 9, 1988·Science·J A ThompsonT Maciag
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J A ThompsonT Maciag
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I VlodavskyM Klagsbrun
Apr 1, 1982·Circulation Research·O Hudlická

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Citations

Jun 29, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·R J LahamD Hung
Mar 16, 2004·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Ning WuWu Lu
Feb 22, 2001·International Journal of Cardiology·M FujitaS Sasayama
Jul 20, 2002·International Journal of Cardiology·Anastasia A KatiniotiPavlos Toutouzas
Feb 17, 2000·Journal of the American College of Cardiology·M A RajanayagamE F Unger
Mar 16, 2012·Gene Therapy·M G KatzC R Bridges
Nov 20, 2009·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Jihun LeeMichael Blaber
Jul 27, 2002·Journal of Interventional Cardiology·Kishore J HarjaiCindy L Grines
Mar 13, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Janet R ManningJo El J Schultz
Apr 10, 2007·Trends in Cardiovascular Medicine·Kory J Lavine, David M Ornitz
Feb 21, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Roger J LahamFrank W Sellke
Mar 18, 2005·International Journal of Cardiology·Theofilos M KolettisDimitrios A Sideris
Oct 28, 2015·BioMed Research International·Marc-Antoine IsorniPhilippe Menasche
Jan 9, 2003·Expert Opinion on Biological Therapy·Alessandra B Ennett, David J Mooney
Nov 11, 1998·Journal of Vascular Surgery·R L BushD N Pearson
Sep 23, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mikhail Y MaslovMark A Lovich
Feb 2, 2000·Circulation·R KornowskiS E Epstein
Apr 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·M S Pepper

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