Intrapericardial procaine affects volume expansion-induced fos immunoreactivity in unanesthetized rats

Experimental Neurology
J T CunninghamMargaret J Sullivan

Abstract

Acute volume expansion is associated with a specific pattern of Fos expression and the goal of the present study was to evaluate the contribution of cardiac receptors to this response. Adult male rats were instrumented with pericardial catheters introduced at the level of the thymus. Rats were also catheterized for measuring blood pressure, heart rate, central venous pressure, and intravenous infusion. Each rat received a 200-microl intrapericardial (i.p.c) injection of 2% procaine or 0.9% NaCl. Rats were then volume expanded with isotonic saline (10% body weight in 10 min) or given a control infusion (0.01 ml/min for 10 min). Ninety minutes after the start of the infusion, the rats were anesthetized and perfused transcardially. Their brains were sectioned and processed for Fos, dopamine-beta-hydroxylase, and oxytocin immunocytochemistry. Volume expansion plus i.p.c. saline produced a significant increase in Fos expression in the nucleus of the solitary tract, the ventrolateral medulla, the area postrema, the locus coeruleus, the paraventricular nucleus of the hypothalamus, the perinuclear zone of the supraoptic nucleus, and oxytocin neurons in the supraoptic nucleus. The i.p.c. procaine significantly blocked Fos expression pro...Continue Reading

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Citations

Dec 21, 2002·Acta Physiologica Scandinavica·P J MuellerE M Hasser
Apr 15, 2004·Experimental Neurology·B Matthew HoweJ Thomas Cunningham
Feb 11, 2004·Progress in Biophysics and Molecular Biology·J Thomas CunninghamDavid Murphy
Feb 6, 2004·Progress in Neurobiology·R A L Dampney, J Horiuchi
Jun 17, 2008·The Journal of Physiology·Juliana Irani Fratucci De GobbiAlan Kim Johnson
Jul 20, 2011·Research in Microbiology·Gipsi Lima-MendezRaphael Leplae
Oct 30, 2004·Stress : the International Journal on the Biology of Stress·Celia D Sladek
Oct 2, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lisa L JiJ Thomas Cunningham
Dec 28, 2006·Hypertension·J Thomas CunninghamSteve Mifflin
Aug 7, 2008·Journal of Neuroscience Research·Lisandra Oliveira MargathoJosé Antunes-Rodrigues
Sep 12, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mauricio BenedettiLucila L K Elias
Nov 25, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Helmut B GottliebJ Thomas Cunningham
Jan 21, 2003·Journal of Applied Physiology·Patrick J Mueller, Eileen M Hasser
May 10, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A Kantzides, E Badoer

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