Intrapericardial streptokinase for purulent pericarditis

Surgery Today
Hasan Ekim, Recep Demirbağ

Abstract

Purulent pericarditis has become a rare disease since the introduction of antibiotics into clinical practice. Standard management consists of antibiotics and surgical drainage. In this study we also instilled streptokinase to obliterate the loculations and fibrin strands in patients with purulent pericarditis. Between October 1997 and October 2002, we treated nine children with purulent pericarditis by pericardial drainage with streptokinase instillation and antibiotics. There were five boys and four girls aged between 3 and 13 years, with a mean age of 6.7 +/- 2.9 years. Pericardiocentesis revealed purulent effusion of 180-650 ml in the pericardial space in all patients. Blood pressure increased and central venous pressure decreased after the pericardial empyema was evacuated in all patients. None of the patients had systemic bleeding, arrhythmias, or hypotension suggesting an anaphylactic reaction. We found intrapericardial streptokinase to be safe and effective for dissolving fibrin layers and removing loculations, resulting in complete pericardial drainage. Therefore, intrapericardial streptokinase should be instilled to prevent constrictive pericarditis.

Citations

Sep 6, 2005·Current Treatment Options in Cardiovascular Medicine·Karen S Rheuban
May 15, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Michael T BighamHector R Wong
Apr 9, 2009·Medicine·Shailja V ParikhEllen C Keeley
Dec 14, 2011·Pediatric Emergency Care·Orli MeggedDavid Kleid
May 18, 2011·Critical Care : the Official Journal of the Critical Care Forum·Pascal AugustinPhilippe Montravers
Sep 2, 2011·Acta chirurgica Iugoslavica·Arsen D RistićBernhard Maisch
Mar 14, 2014·Paediatrics and International Child Health·R C IdehT Corrah
Jan 27, 2007·Pharmacotherapy·Kelly K JohnsonParag Patel

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