Intraperitoneal administration of mesenchymal stem cells ameliorates acute dextran sulfate sodium-induced colitis by suppressing dendritic cells

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Aleksandar NikolicVladislav Volarevic

Abstract

Dendritic cells (DCs) have important pathogenic role in the induction and progression of ulcerative colitis (UC), but their role in mesenchymal stem cells (MSCs)-mediated suppression of colon injury and inflammation is not revealed. By using dextran sodium sulfate (DSS)-induced colitis, a well-established murine model of UC, we examined effects of MSCs on phenotype and function of colon infiltrating DCs. Clinical, histological, immunophenotypic analysis and passive transfer of MSCs-primed DCs were used to evaluate capacity of MSC to suppress inflammatory phenotype of DCs in vivo. Additionally, DCs:MSCs interplay was also investigated in vitro, to confirmed in vivo obtained findings. Intraperitoneally administered MSCs (2 × 106) significantly reduced progression of DSS-induced colitis and reduced serum levels of inflammatory cytokines (IL-1β, IL-12, and IL-6). Passive transfer of in vivo MSCs-primed DCs reduced severity of colitis while passive transfer of MSCs-non-primed DCs aggravated DSS-induced colitis. Through the secretion of immunomodulatory Galectin 3, MSCs, in paracrine manner, down-regulated production of inflammatory cytokines in DCs and attenuated expression of co-stimulatory and major histocompatibility complex clas...Continue Reading

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Citations

Nov 7, 2019·International Journal of Molecular Sciences·Joan Oliva
Mar 19, 2020·Frontiers in Immunology·Tasuku OgitaTakeshi Shimosato
Dec 24, 2018·Therapeutic Advances in Gastroenterology·Aleksandar AcovicVladislav Volarevic
Dec 9, 2020·Journal of Clinical Medicine·Seyed-Kazem Hosseini-AslFeridoun Karimi-Busheri
Mar 24, 2021·Immunology Letters·Ivan M Srejovic, Miodrag L Lukic

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