Intraperitoneal chemotherapy in the treatment of advanced ovarian cancer

Journal de gynécologie, obstétrique et biologie de la reproduction
J M ClasseL Gladieff

Abstract

The standard treatment for advanced ovarian cancer consist in complete surgical debulking and intravenous platin and taxane based chemotherapy. Despite research efforts, a lot of patients still die from peritoneal carcinomatosis. The aim of our work was to present the state of art about intraperitoneal chemotherapy. Intraperitoneal chemotherapy (IPC): three multi-institutional randomised trials showed that platin based IPC gave better results in term of overall and disease free survival when compared to standard intravenous treatment. Even so, IPC is not yet becoming a new international standard of treatment because a high rate of morbidity. Hyperthermic Intraperitoneal chemotherapy (HIPEC) represents an innovative alternative to IPC. HIPEC is based on a complete surgical debulking without any visible mass and an intraperitoneal chemotherapy with synergy of hyperthermia. Phase II trails have shown its feasibility. Randomised trials are needed to assess its efficiency in improving survival.

References

Jun 1, 1988·American Journal of Clinical Oncology·J R OlesonD S Kapp
Apr 1, 1986·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·H S Reinhold, B Endrich
Dec 1, 1982·Annals of Internal Medicine·S B HowellM Green
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J P GuastallaJ Renard
Apr 2, 1997·Journal of the National Cancer Institute·R L Dedrick, M F Flessner
Jan 8, 1999·Cell Stress & Chaperones·J L Roti RotiM Xu
Mar 12, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D EliasM Ducreux
Aug 7, 2004·Gynecologic Oncology·Ki Sung RyuJoon Mo Lee
Dec 14, 2004·The New England Journal of Medicine·Stephen A Cannistra
Apr 13, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J GoriN Felci
Apr 22, 2005·Journal of Surgical Oncology·Trevor W ReichmanLawrence E Harrison
Oct 22, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A du BoisUNKNOWN Organizational team of the two prior International OCCC
Apr 20, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F RaspagliesiM Deraco
May 5, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L González-BayónG Ortega-Pérez
Jun 21, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K SchmidH Drexler
May 15, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L BijelicP H Sugarbaker
Feb 6, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A Gadducci, P F Conte

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Citations

Feb 25, 2011·Archives of Gynecology and Obstetrics·Kazuko FujwaraMasatoshi Hori

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