Intraperitoneal chemotherapy with taxanes for ovarian cancer with peritoneal dissemination

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Eelco de BreeDimitris D Tsiftsis

Abstract

Paclitaxel and docetaxel are currently the two clinically available taxanes. The combination of a taxane and a platinum compound has become the systemic chemotherapy of choice for primary ovarian cancer. Despite the high activity of these drugs in systemic chemotherapy, the majority of patients with advanced ovarian cancer will develop recurrent disease and ultimately decease of this disease. Therefore, more effective systemic chemotherapy regimens or alternative treatment modalities are warranted. Intraperitoneal chemotherapy is such an alternative treatment option. Pharmacokinetic studies on intraperitoneal administration of paclitaxel and docetaxel demonstrated very high locoregional drug concentrations and exposure. Their activity and response seem to be dose-dependent and hence higher efficacy with limited systemic toxicity is to be expected. Intraperitoneal chemotherapy may be combined intraoperatively with hyperthermia, which enhances tissue penetration and cytotoxic activity of many drugs. The data concerning thermal enhancement of taxanes are inconsistent, but at the high locoregional concentrations provided by intraperitoneal drug administration such a thermal enhancement seems to exist. Clinical studies have clearly ...Continue Reading

References

Jan 5, 1994·Journal of the National Cancer Institute·E C KohnF P Ognibene
Apr 2, 1997·Journal of the National Cancer Institute·R L Dedrick, M F Flessner
Feb 11, 2000·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·A CividalliD T Danesi
Apr 22, 2000·Cancer Treatment Reviews·L S HofstraP H Willemse
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mace L RothenbergDavid S Alberts
Jun 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George A OmuraSusan G Arbuck
Feb 21, 2004·CA: a Cancer Journal for Clinicians·Ahmedin JemalUNKNOWN American Cancer Society
Sep 24, 2004·Journal of Surgical Oncology·Faheez MohamedPaul H Sugarbaker
Nov 18, 2004·Journal of the National Cancer Institute·Paul A VaseyUNKNOWN Scottish Gynaecological Cancer Trials Group

❮ Previous
Next ❯

Citations

Nov 3, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F C Muñoz-CasaresA Gómez-Portilla
Nov 18, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Francisco C Muñoz-CasaresJordi Muntané
Dec 30, 2011·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M MullerJ-M Classe
Sep 18, 2010·Cancer Chemotherapy and Pharmacology·Ilaria De StefanoDaniela Gallo
Sep 26, 2013·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Nada Oršolic, Nikola Car
Jul 3, 2007·Neoplasia : an International Journal for Oncology Research·Edmond AuzenneJim Klostergaard
Sep 16, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rolf D Issels
Aug 30, 2008·Surgical Oncology Clinics of North America·James H Muchmore, Harold J Wanebo
Mar 31, 2009·The Journal of Surgical Research·Daisuke SomaHirokazu Nagawa
Apr 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nada Oršolić, Nikola Car
Mar 27, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Tao HuangDianpeng Feng
Apr 28, 2011·Molecular Imaging·Lucia M A CraneGooitzen M van Dam
Aug 1, 2012·Expert Review of Anticancer Therapy·Eelco de Bree, C William Helm
Apr 17, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Tao HuangDian-Peng Feng
Mar 16, 2019·Cancers·Valeria CarinaGianluca Giavaresi
Jun 1, 2017·Pleura and Peritoneum·Eelco de BreeOdysseas Zoras
Aug 18, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W J KoemansJ W van Sandick
Jun 19, 2021·Annals of Surgical Oncology·Aditi BhattOlivier Glehen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.