Intraperitoneal insulin infusion improves the depletion in choline-containing phospholipids of lipoprotein B particles in type I diabetic patients

Metabolism: Clinical and Experimental
B GuerciC Fievet

Abstract

Insulin-dependent diabetes mellitus (IDDM) is characterized by altered composition of atherogenic lipoproteins, especially a depletion in choline-containing phospholipids (PL) of apolipoprotein (apo) B lipoproteins (LpB). To determine the effects of continuous intraperitoneal (IP) insulin infusion (CIPII) on this qualitative lipoprotein abnormality, we compared lipoprotein profiles of 14 IDDM patients treated by continuous subcutaneous insulin infusion (CSII) and at 2 and 4 months after treatment with CIPII using an implantable pump. IDDM patients were in fair metabolic control and were compared with 14 healthy control subjects matched for sex, age, body mass index, and plasma lipids. The following parameters were studies: hemoglobin A1c (HbA1c), monthly blood glucose, daily insulin dose (units per kilogram per day), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol, apo A-I, and apo B. Choline-containing PL were assessed in plasma and in apo B- and no-apo B-containing lipoprotein particles (LpB and Lp no B). As compared with the control group, plasma PL and LpB-PL were significantly lower in IDDM patients treated by CSII (2.95 +/- 0.26 v 3.30 +/- 0.45 mmol/...Continue Reading

References

Aug 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·M TakayamaI Tanimizu
Jun 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·E L Bierman
Nov 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J P SlotteE L Bierman
May 1, 1988·Metabolism: Clinical and Experimental·S L ShumakG Steiner
Dec 1, 1985·Metabolism: Clinical and Experimental·R W Stout
Jul 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A KuksisJ A Little

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Citations

Feb 1, 2012·European Journal of Clinical Investigation·John D BagdadeChristopher Reardon
Jul 22, 2009·Diabetes Research and Clinical Practice·John BagdadeDiana Lee

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