Intraperitoneal transplantation of bioengineered humanized liver grafts supports failing liver in acute condition

Materials Science & Engineering. C, Materials for Biological Applications
Sandeep Kumar VishwakarmaAleem Ahmed Khan

Abstract

Acute liver failure (ALF) is one of the most devastating fatal conditions which have posed crucial challenges to the clinicians and researchers for identifying permanent cure. Currently liver transplantation has been considered as the only managerial option. However it's wider applicability has been limited owing to non-availability of quality donor organs, cost-intensiveness, surgical hitches, life-long use of immunosuppressive drugs and long-term complications. Since last decades, several liver support systems have been developed for the management of failing liver in acute condition. However, the major limitation has been the lack of natural biological support and long-term survival of the grafts post-transplantation. Repopulation of decellularized xenogeneic organs is one of the emerging technologies for development of humanized neo-organs for demanding regenerative application. However, the earlier reported studies do not fulfil the insistence to provide immunologically tolerable humanized liver grafts for clinical applications. Here we demonstrate an efficient approach to generate transplantable humanized liver grafts which provides long-term support to the failing liver in Acute Liver Failure (ALF) animal models. These b...Continue Reading

Citations

Jul 10, 2019·Bioengineering·Shicheng YeKerstin Schneeberger
Jan 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Chong PengKe-Er Huang
Nov 6, 2020·Therapeutic Advances in Gastroenterology·Guang-Peng ZhouZhi-Jun Zhu
Nov 9, 2021·Frontiers in Bioengineering and Biotechnology·Ibrahim FathiMasafumi Goto

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