Intrapituitary regulatory system of proliferation of mammotrophs in the pituitary gland

Zoological Science
Sumio Takahashi

Abstract

Anterior pituitary cells produce growth factors plus cytokines and their receptors. Although some of these pituitary growth factors and cytokines are known to be involved in the control of cell differentiation, proliferation and hormone production in the pituitary gland, their physiological roles remain unknown. Lots of evidence indicates that they are involved in the regulation of prolactin-secreting mammotroph cell proliferation. The regulation of mammotroph functions is a suitable system for understanding the intrapituitary regulatory system operated by growth factors and cytokines, since mammotrophs are the most actively proliferating cells in female pituitary glands. This review discusses the possible intrapituitary regulation of mammotroph differentiation and proliferation in rat and mouse pituitaries.

Citations

Aug 16, 2005·Endocrinology·G JaitaA Seilicovich
Apr 24, 2013·Molecular Endocrinology·Daniela RadlEmiliana Borrelli
Apr 16, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Haruo NogamiSadakazu Aiso
Oct 20, 2018·Journal of Cellular and Molecular Medicine·Jun GaoRenzhi Wang

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